Synchronized Assembly of Gold Nanoparticles Driven by a Dynamic DNA-Fueled Molecular Machine
Synchronized Assembly of Gold Nanoparticles Driven by a Dynamic DNA-Fueled Molecular Machine
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由动态 DNA 驱动的分子机器驱动金纳米粒子的同步组装
DOI：
10.1021/ja304746k
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发表时间：
2012-07-04
影响因子：
15
通讯作者：
Liang, Haojun
中科院分区：
文献类型：
--
作者：
Song, Tingjie;Liang, Haojun
本文提出了一种由动态DNA分子机器驱动的金纳米粒子组装策略。在这台机器中，DNA功能化的金纳米粒子的聚集是由一系列的支点介导的DNA链置换反应。AuNP的聚集速率可以通过控制寡核苷酸催化剂的量来调节。动态DNA燃料分子机器的多功能性在两个组件的“或”和“与”逻辑门的建设已被证明。这种新建立的策略可能会发现广泛的潜在应用，在建立一个“接口”，允许结合的链置换为基础的特性的DNA与无机纳米粒子的独特的组装性能，最终导致制造范围广泛的复杂的多组分设备和架构。
A strategy for gold nanoparticle (AuNP) assembly driven by a dynamic DNA-fueled molecular machine is revealed here. In this machine, the aggregation of DNA-functionalized AuNPs is regulated by a series of toehold-mediated strand displacement reactions of DNA. The aggregation rate of the AuNPs can be regulated by controlling the amount of oligonucleotide catalyst. The versatility of the dynamic DNA-fueled molecular machine in the construction of two-component "OR" and "AND" logic gates has been demonstrated. This newly established strategy may find broad potential applications in terms of building up an "interface" that allows the combination of the strand displacement-based characteristic of DNA with the distinct assembly properties of inorganic nanoparticles, ultimately leading to the fabrication of a wide range of complex multicomponent devices and architectures.