Glycated hemoglobin level is strongly related to the prevalence of carotid artery plaques with high echogenicity in nondiabetic individuals

DOI：

10.1161/01.cir.0000136809.55141.3b

发表时间：

2004-07-27

期刊：

CIRCULATION

影响因子：

37.8

通讯作者：

中科院分区：

医学1区

文献类型：

作者：

Jorgensen, L;Jenssen, T;Jacobsen, BK

背景-高水平的HbA（1c）与死亡率增加和动脉粥样硬化风险增加（评估为颈动脉内膜中层厚度或斑块患病率）相关。在本人群为基础的研究中，我们研究了糖化血红蛋白（1c）和斑块的患病率之间的关联，强调斑块回声在未诊断为diabetes.Methods和Results-HbA（1c）的测量和超声检查的颈动脉进行了5960例（3026名妇女，2934名男子）25至84岁。斑块形态从低回声（软斑块）到强回声（硬斑块）分为4组。HbA（1c）分为5组：6.4%。颈动脉斑块患病率随HbA（1c）水平的升高而升高（线性趋势P = 0.002）。在HbA（1c）最高组（>6.4%）中，硬斑块与无斑块的OR为5.8，而在HbA（1c）最低组（

Background-High levels of HbA(1c) have been associated with increased mortality and an increased risk of atherosclerosis assessed as carotid intima-media thickness or plaque prevalence. In the present population-based study, we examined the association between HbA(1c) and plaque prevalence with emphasis on plaque echogenicity in subjects not diagnosed with diabetes.Methods and Results-HbA(1c) measurements and ultrasonography of the carotid artery were performed in 5960 subjects ( 3026 women, 2934 men) 25 to 84 years of age. Plaque morphology was categorized into 4 groups from low echogenicity ( soft plaque) to strong echogenicity ( hard plaque). HbA(1c) was categorized into 5 groups: 6.4%. Carotid plaque prevalence increased with increasing HbA(1c) level (P for linear trend = 0.002). The OR for hard plaques versus no plaques was 5.8 in the highest HbA(1c) group (>6.4%) compared with subjects in the lowest group (

Glycated hemoglobin level is strongly related to the prevalence of carotid artery plaques with high echogenicity in nondiabetic individuals - The Tromso Study

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