Cytokine immunoreactivity in plasma does not change after moderate endurance exercise.
Cytokine immunoreactivity in plasma does not change after moderate endurance exercise.
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中等耐力运动后，血浆中的细胞因子免疫反应性不会改变。
DOI：
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发表时间：
1992
影响因子：
3.3
通讯作者：
M. J. Weidemann
中科院分区：
文献类型：
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作者：
J. A. Smith;R. Telford;M. Baker;A. Hapel;M. J. Weidemann
我们研究了循环细胞因子浓度的增加是否可能是运动诱导的血液中性粒细胞启动的原因（J. A. Smith等，Int. J. Sports Med.11：179-187，1990）。在60%最大摄氧量下骑自行车1小时之前和之后，通过免疫测定法测量了经过训练和未经训练的人类受试者的肿瘤坏死因子-α、白细胞介素-（IL）1 β、IL-6、粒细胞-巨噬细胞集落刺激因子和新蝶呤的血浆浓度。C反应蛋白和肌酸激酶（CK）在运动前和运动后24小时也被测量作为“急性期反应”和肌肉损伤的标志物（C。Taylor等，J.Appl.Physiol.62：464-469，1987）。在运动后观察到的细胞因子或新喋呤的血浆浓度的小的变化，在训练和未经训练的受试者没有显着不同的对照组nonexercised科目。然而，未经训练的受试者确实表现出急性相反应（P = 0.04）运动后24小时没有额外的释放到血浆中的CK。基线训练差异仅限于CK活性的两倍升高（P = 0.04）。结果表明，循环细胞因子不太可能是中度耐力运动后观察到的嗜中性粒细胞杀微生物活性的启动的原因（J.A. Smith等，Int. J. Sports Med.11：179-187，1990）。
We investigated whether increased concentrations of circulating cytokines may be responsible for exercise-induced priming of blood neutrophils (J. A. Smith et al. Int. J. Sports Med. 11: 179-187, 1990). The plasma concentrations of tumor necrosis factor-alpha, interleukin- (IL) 1 beta, IL-6, granulocyte-macrophage colony-stimulating factor, and neopterin in trained and untrained human subjects were measured by immunoassay before and after 1 h of cycling at 60% of maximal oxygen uptake. C-reactive protein and creatine kinase (CK) were also measured before and 24 h after exercise as markers of the "acute-phase response" and muscle damage (C. Taylor et al. J. Appl. Physiol. 62: 464-469, 1987), respectively. The small changes in the plasma concentrations of cytokines or neopterin observed after exercise in both trained and untrained subjects were not significantly different to those found in a control group of nonexercised subjects. However, untrained subjects did exhibit an acute-phase response (P = 0.04) 24 h after exercise without additional release of CK into plasma. Baseline training differences were confined to a twofold elevation in CK activity (P = 0.04). The results show that circulating cytokines are unlikely to be responsible for the priming of neutrophil microbicidal activity observed after moderate endurance exercise (J. A. Smith et al. Int. J. Sports Med. 11: 179-187, 1990).