Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease
Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease
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DOI：
10.1155/2012/382082
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发表时间：
2012-01-01
影响因子：
4.6
通讯作者：
Pankuweit, Sabine
中科院分区：
文献类型：
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作者：
Karatolios, Konstantinos;Moosdorf, Rainer;Pankuweit, Sabine
背景炎性和血管生成细胞因子在炎性心包积液患者中的作用仍然不确定。方法.我们通过ELISA法评估了22例自身反应性和11例病毒性炎性心包积液（PE）患者的心包和血清VEGF、bFGF、IL-1 β和TNF-α水平，并对26例接受冠状动脉旁路移植术的冠心病（CAD）患者的心包液（PF）和血清进行了对照。结果在自身反应性肺栓塞（自身反应性肺栓塞P = 0.006，病毒性肺栓塞P <0.001）和血清（自身反应性肺栓塞P <0.001，病毒性肺栓塞P <0.001）中，自身反应性肺栓塞和病毒性肺栓塞患者的VEGF水平均显著高于CAD患者。炎性PE和CAD患者心包bFGF水平高于血清水平（P
Background. The role of inflammatory and angiogenic cytokines in patients with inflammatory pericardial effusion still remains uncertain. Methods. We assessed pericardial and serum levels of VEGF, bFGF, IL-1 beta and TNF-alpha by ELISA in patients with inflammatory pericardial effusion (PE) of autoreactive (n = 22) and viral (n = 11) origin, and for control in pericardial fluid (PF) and serum (n = 26) of patients with coronary artery disease (CAD) undergoing coronary artery bypass graft surgery. Results. VEGF levels were significantly higher in patients with autoreactive and viral PE than in patients with CAD in both PE (P = 0, 006 for autoreactive and P < 0, 001 for viral PE) and serum (P < 0, 001 for autoreactive and P < 0, 001 for viral PE). Pericardial bFGF levels were higher compared to serum levels in patients with inflammatory PE and patients with CAD (P