MECHANISMS OF REGROWTH OF THE BULBOSPINAL SEROTONIN SYSTEM FOLLOWING 5,6-DIHYDROXYTRYPTAMINE INDUCED AXOTOMY .1. BIOCHEMICAL CORRELATES
MECHANISMS OF REGROWTH OF THE BULBOSPINAL SEROTONIN SYSTEM FOLLOWING 5,6-DIHYDROXYTRYPTAMINE INDUCED AXOTOMY .1. BIOCHEMICAL CORRELATES
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DOI：
10.1016/0006-8993(80)90318-2
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发表时间：
1980-01-01
期刊：
影响因子：
2.9
通讯作者：
WIKLUND, L
中科院分区：
文献类型：
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作者：
BJORKLUND, A;WIKLUND, L
在 5,6-二羟色胺 (5,6-DHT) 诱导的轴突切除术后 1-2 周至 8 个月内追踪大鼠球脊髓血清素神经元的再生。注射神经毒素后，测定内源性血清素 (5-HT) 和 [3H]5-HT 摄取，并测量体外 [3H]色氨酸 ([3H]TP) 转化为 [3H]5-HT 和 [3H]5-HIAA。在化学轴突化的血清素神经元的再生过程中，神经递质生物合成机制发生了广泛的恢复。脊髓中不完全神经支配区域的递质周转增加和神经支配过度的脑干区域的周转减少意味着区域补偿机制可以减轻再生末梢分布异常的功能后果。轴突再生、递质利用率的增加以及不完全再生时受体超敏感性的发展相结合，导致某个区域的部分神经支配，可能会有效恢复中枢神经系统的正常功能。
The regrowth of the rat bulbospinal serotonin neurons after 5,6-dihydroxytryptamine (5,6-DHT)-induced axotomy was followed between 1-2 wk and 8 mo. after neurotoxin injection, using determinations of endogenous serotonin (5-HT) and [3H]5-HT uptake, and measurements of the conversion of [3H]tryptophan ([3H]TP) into [3H]5-HT and [3H]5-HIAA in vitro. An extensive recovery of the neurotransmitter biosynthetic machinery occurred during regeneration of the chemically axotomized serotonin neurons. Increased transmitter turnover in the incompletely reinnervated areas in the spinal cord and decreased turnover in the hyperinnervated brain stem areas imply that regional compensatory mechanisms may alleviate the functional consequences of the abnormal distribution of the regenerated terminals. A combination of axonal regeneration, increased utilization of the transmitter and development of receptor supersensitivity at incomplete regeneration, resulting in a partial reinnervation of an area, may become efficient in restoring normal function in the CNS.