Inheritance and memory of stress-induced epigenome change: roles played by the ATF-2 family of transcription factors.

Inheritance and memory of stress-induced epigenome change: roles played by the ATF-2 family of transcription factors.
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应激诱导的表观基因组变化的遗传和记忆:转录因子 ATF-2 家族所发挥的作用。

DOI:
10.1111/j.1365-2443.2012.01587.x
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发表时间:
2012-04
期刊:
Genes to cells : devoted to molecular & cellular mechanisms
影响因子:
--
通讯作者:
Ishii S
Ishii S
中科院分区:
其他
文献类型:
--
作者:
Seong KH;Maekawa T;Ishii S

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关于压力遗传效应的数据一直在积累,也提出了一些机械性的见解,如表观遗传调控。特别是,拉马克遗传的现代观点似乎受到了压力诱导的表观遗传变化可以遗传的发现的影响。本文综述了应激效应的遗传机制及其可能机制的研究进展。特别是,我们专注于由ATF-2转录因子家族介导的应激诱导的表观遗传学变化。
Data on the inheritance-of-stress effect have been accumulating and some mechanistic insights, such as epigenetic regulation, have also been suggested. In particular, the modern view of Lamarckian inheritance appears to be affected by the finding that stress-induced epigenetic changes can be inherited. This review summarizes the current data on the inheritance of stress effect and possible mechanisms involved in this process. In particular, we focus on the stress-induced epigenetic changes mediated by the ATF-2 family of transcription factors.
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