IL-17: overview and role in oral immunity and microbiome.
IL-17: overview and role in oral immunity and microbiome.
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DOI：
10.1111/odi.12598
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发表时间：
2017-10
期刊：
影响因子：
3.8
通讯作者：
Moutsopoulos NM
中科院分区：
文献类型：
--
作者：
Abusleme L;Moutsopoulos NM
白细胞介素-17（IL-17）是一种多方面的细胞因子，在免疫保护和免疫病理学中具有不同的作用。IL-17在粘膜和屏障表面的免疫监视中具有公认的作用，但也越来越多地被认为是自身免疫和慢性炎症环境中免疫病理学的驱动因素。目前的综述介绍了IL-17生物学的基本方面，并研究了IL-17的保护和致病作用，重点是口腔粘膜免疫和炎症。特别强调了IL-17反应作为“塑造口腔屏障微生物组”的催化剂的作用。
Interleukin‐17 (IL‐17) is a multifaceted cytokine with diverse roles in both immune protection and also immunopathology. IL‐17 has a well‐recognized role in immune surveillance at mucosal and barrier surfaces, but also has been increasingly implicated as a driver of immunopathology in settings of autoimmunity and chronic inflammation. The current review introduces basic aspects of IL‐17 biology and examines the protective and pathogenic roles of IL‐17 with a focus on oral mucosal immunity and inflammation. Specific emphasis is given to the role of the IL‐17 response as a catalyst in ‘shaping the microbiome at the oral barrier’.