The T6SSs of Pseudomonas aeruginosa Strain PAO1 and Their Effectors: Beyond Bacterial-Cell Targeting.
The T6SSs of Pseudomonas aeruginosa Strain PAO1 and Their Effectors: Beyond Bacterial-Cell Targeting.
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DOI：
10.3389/fcimb.2016.00061
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发表时间：
2016
影响因子：
5.7
通讯作者：
Bleves S
中科院分区：
文献类型：
--
作者：
Sana TG;Berni B;Bleves S
铜绿假单胞菌是导致囊性纤维化患者慢性肺定植和医院急性感染等多种疾病的条件致病菌。铜绿假单胞菌对几种宿主致病的能力主要是由于不同的分泌系统。其中，铜绿假单胞菌编码三种六型分泌系统（T6SS），命名为H1-至H3-T6SS，作用于原核生物和/或真核细胞。它们彼此独立，注入不同的毒素，与宿主细胞中的不同成分相互作用。本文综述了这些t6ss在PAO1菌株中的作用，以及注射的毒素和它们的靶点。虽然H1-T6SS仅通过至少七种不同的毒素参与抗原核活性，但H2-T6SS和H3-T6SS也能够靶向原核细胞和真核细胞。此外，最近的研究表明，H2-和H3-T6SS通过注射至少三种不同的毒素在上皮细胞侵袭中发挥作用。T6SS效应体的多样性令人震惊，其他效应体仍有待发现。在这篇综述中，我们提出了其他推测的铜绿假单胞菌菌株PAO1 t6ss依赖性效应物的表。总之，P. aeruginosa的t6ss是帮助对抗其他细菌的生态位的重要系统，在致病性过程中也很重要。
Pseudomonas aeruginosa is an opportunistic pathogen responsible for many diseases such as chronic lung colonization in cystic fibrosis patients and acute infections in hospitals. The capacity of P. aeruginosa to be pathogenic toward several hosts is notably due to different secretion systems. Amongst them, P. aeruginosa encodes three Type Six Secretion Systems (T6SS), named H1- to H3-T6SS, that act against either prokaryotes and/or eukaryotic cells. They are independent from each other and inject diverse toxins that interact with different components in the host cell. Here we summarize the roles of these T6SSs in the PAO1 strain, as well as the toxins injected and their targets. While H1-T6SS is only involved in antiprokaryotic activity through at least seven different toxins, H2-T6SS and H3-T6SS are also able to target prokaryotic as well as eukaryotic cells. Moreover, recent studies proposed that H2- and H3-T6SS have a role in epithelial cells invasion by injecting at least three different toxins. The diversity of T6SS effectors is astounding and other effectors still remain to be discovered. In this review, we present a table with other putative P. aeruginosa strain PAO1 T6SS-dependent effectors. Altogether, the T6SSs of P. aeruginosa are important systems that help fight other bacteria for their ecological niche, and are important in the pathogenicity process.