Renal clearable inorganic nanoparticles: a new frontier of bionanotechnology
Renal clearable inorganic nanoparticles: a new frontier of bionanotechnology
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DOI：
10.1016/j.mattod.2013.11.003
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发表时间：
2013-12-01
期刊：
影响因子：
24.2
通讯作者：
Zheng, Jie
中科院分区：
文献类型：
--
作者：
Liu, Jinbin;Yu, Mengxiao;Zheng, Jie
虽然具有可调和多样化材料特性的无机纳米颗粒（NPs）为新型生物医学技术开辟了前所未有的机会，但将这些NPs转化为临床实践却受到其在健康组织/器官中非特异性积累引起的毒性的严重阻碍。在过去几年中，肾可清除无机纳米颗粒的出现使得解决这一长期挑战成为可能。本文综述了肾可清除无机纳米粒子的尺寸、形状、表面化学和生物降解方面的考虑，以及它们在肿瘤靶向方面优于传统非肾可清除纳米粒子和小分子造影剂的优势。最后，一些材料化学的挑战，在发展中的肾可清除的无机纳米粒子和它们的生物医学意义以外的肿瘤靶向进行了讨论。
While inorganic nanoparticles (NPs) with tunable and diverse material properties open up unprecedented opportunities for novel biomedical technologies, translating these NPs into clinical practices has been severely hampered by the toxicity induced by their nonspecific accumulation in healthy tissues/organs. In the past few years, the emergence of renal clearable inorganic NPs has made it possible to address this long-term challenge. This review summarizes size, shape, surface chemistry and biodegradation considerations in the design of renal clearable inorganic NPs and their strengths over conventional non-renal clearable NPs and small-molecule contrast agents in tumor targeting. Finally, some materials chemistry challenges in the development of renal clearable inorganic NPs and their biomedical implications beyond tumor targeting are discussed.