Transforming growth factor-β5 expression during early development of Xenopus laevis
Transforming growth factor-β5 expression during early development of Xenopus laevis
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DOI：
10.1016/s0925-4773(00)00326-9
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发表时间：
2000-07-01
影响因子：
2.6
通讯作者：
Dawid, IB
中科院分区：
文献类型：
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作者：
Kondaiah, P;Taira, M;Dawid, IB
转化生长因子-β（TGF-β）超家族的成员在脊椎动物和无脊椎动物的发育过程中发挥各种作用。已从非洲爪蟾中分离出两种同种型，TGF-β 2和TGF-β 5。本文描述了TGF-β 5 mRNA在X.通过整装原位杂交评估。TGF-β 5在第14期胚胎脊索后尖处首次检测到表达，并持续到后期，伴随着脊索附近尾部后壁两侧区域的表达。在后期，在骨水泥腺（第21期左右）和体节（第24-27期）中观察到瞬时表达。此外，在鳃弓（第29-36期）和嗅板（第36期）中也有表达。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
Members of the transforming growth factor-beta (TGF-beta) superfamily play various roles during development in both vertebrates and invertebrates. Two isoforms, TGF-beta 2 and -beta 5, have been isolated from Xenopus laevis. We describe here the localization of TGF-beta 5 mRNA in early embryos of X. laevis, assessed by whole-mount in situ hybridization. The first detectable expression of TGF-beta 5 was seen in the stage 14 embryo at the posterior tip of notochord, which continued to later stages, accompanied by the expression in bilateral regions of posterior wall in the tail region next to the notochord. At later stages, transient expression was seen in the cement gland (around stage 21) and in the somites (stages 24-27). In addition, expression was present in the branchial arches (stage 29-36) and olfactory placodes (stage 36). (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.