PATTERN OF CELL MIGRATION DURING CORTICAL HISTOGENESIS
PATTERN OF CELL MIGRATION DURING CORTICAL HISTOGENESIS
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DOI：
10.1038/203591b0
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发表时间：
1964-01-01
期刊：
影响因子：
64.8
通讯作者：
ROGERS, AW
中科院分区：
文献类型：
--
作者：
BERRY, M;EAYRS, JT;ROGERS, AW
大脑皮层的 HE 神经元件是通过有丝分裂从单个生发层衍生出来的，并通过从心室旁位置向浅层皮层表面迁移的过程获得其确定的排列。自从蒂尔尼*的经典研究以来，人们普遍认为皮质层是由三个连续的迁移波形成的，第一个产生颗粒上层，第二个产生颗粒层，第三个产生颗粒下层。然而，最近，Berry 和 Eayrs* 无法将这一概念与胎儿 X 射线辐射对皮质结构的影响相协调，并假设产生 V 层和 VI 层的神经母细胞在那些注定形成 IV、III 和 II 层的神经母细胞之前迁移。正常动物和受辐射动物的神经元之间的定量比较，以及海马体和新皮质中锥体细胞发育的比较，支持了这一假设。有人建议，通过对氚化胸苷标记的神经母细胞的行为进行研究，可以获得更直接的证据。七组分别在性交后16、17、18、19、20、21和22天的胎鼠分别进行羊膜内注射氚化胸苷。动物在 4 小时和 2、4、6、8、
HE neural elements of the cerebral cortex are derived by mitotic division from a single germinal layer and attain their definitive arrangement through a process of migration from a juxta-ventricular position towards the superficial cortical surface. Since the classical studies of Tilney* it has been generally accepted that the cortical laminæ are formed by three successive migratory waves, the first giving rise to the supragranular, the second to the granular and the third to the infragranular layers. Recently, however, Berry and Eayrs* were unable to reconcile this concept with the effects of foetal X-irradiation on cortical structure and postulated that the neuroblasts giving rise to layers V and VI migrated before those destined to form layers IV, III and II. Quantitative comparisons between neurones of normal and irradiated animals, and comparisons between the development of pyramidal cells in the hippocampus and neocortex, sup-ported this hypothesis. It was suggested that more direct evidence might be obtained from an investigation of the behaviour of neuroblasts labelled with tritiated thymidine. Each of seven groups of foetal rats, aged 16, 17, 18, 19, 20, 21 and 22 days post-coitus respectively, have accordingly been given a single intra-amniotic injection of triti-ated thymidine. Animals were killed 4 h and 2, 4, 6, 8,