Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass.
Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass.
复制标题
骨髓 Adipoq 谱系祖细胞是 M-CSF 的主要细胞来源，主导骨髓巨噬细胞发育、破骨细胞生成和骨量。
作者：
Inoue K;Qin Y;Xia Y;Han J;Yuan R;Sun J;Xu R;Jiang JX;Greenblatt MB;Zhao B
M-CSF是骨髓系细胞的关键生长因子，包括单核细胞、巨噬细胞和破骨细胞。大多数器官的组织常驻巨噬细胞依赖于局部M-CSF。然而，目前尚不清楚骨髓中哪些特定细胞产生M-CSF来维持骨髓稳态。在这里，我们发现adipoq谱系祖细胞，而不是骨髓或外周脂肪组织中的成熟脂肪细胞，是M-CSF的主要细胞来源，这些adipoq谱系祖细胞产生M-CSF的水平远高于成骨细胞谱系细胞产生的水平。高表达CSF1的adipoq系祖细胞也存在于人骨髓中。骨髓adipoq谱系祖细胞中M-CSF的缺乏会显著减少骨髓巨噬细胞和破骨细胞的产生，导致小鼠出现严重的骨质疏松。此外，骨髓adipoq -谱系祖细胞中M-CSF的缺失可以显著减轻去卵巢小鼠的骨质疏松症。我们的研究结果确定了骨髓adipoq谱系祖细胞是骨髓中M-CSF的主要细胞来源，并揭示了它们对骨髓巨噬细胞发育、破骨细胞发生、骨稳态和病理性骨质流失的重要贡献。
M-CSF is a critical growth factor for myeloid lineage cells, including monocytes, macrophages, and osteoclasts. Tissue-resident macrophages in most organs rely on local M-CSF. However, it is unclear what specific cells in the bone marrow produce M-CSF to maintain myeloid homeostasis. Here, we found that Adipoq-lineage progenitors but not mature adipocytes in bone marrow or in peripheral adipose tissue, are a major cellular source of M-CSF, with these Adipoq-lineage progenitors producing M-CSF at levels much higher than those produced by osteoblast lineage cells. The Adipoq-lineage progenitors with high CSF1 expression also exist in human bone marrow. Deficiency of M-CSF in bone marrow Adipoq-lineage progenitors drastically reduces the generation of bone marrow macrophages and osteoclasts, leading to severe osteopetrosis in mice. Furthermore, the osteoporosis in ovariectomized mice can be significantly alleviated by the absence of M-CSF in bone marrow Adipoq-lineage progenitors. Our findings identify bone marrow Adipoq-lineage progenitors as a major cellular source of M-CSF in bone marrow and reveal their crucial contribution to bone marrow macrophage development, osteoclastogenesis, bone homeostasis, and pathological bone loss.
op/op 小鼠先天性石骨症的血液学特征。巨噬细胞分化异常的可能机制。
影响因子：
15.3
作者：
Wiktor-Jedrzejczak, W W;Ahmed, A;Szczylik, C;Skelly, R R
通讯作者：
Skelly, R R