"Click"-Inspired Chemistry in Macromolecular Science: Matching Recent Progress and User Expectations
"Click"-Inspired Chemistry in Macromolecular Science: Matching Recent Progress and User Expectations
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DOI：
10.1021/ma501386v
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发表时间：
2015-01-13
期刊：
影响因子：
5.5
通讯作者：
Du Prez, Filip E.
中科院分区：
文献类型：
--
作者：
Espeel, Pieter;Du Prez, Filip E.
今年，通过探索点击基准铜催化叠氮化物/炔环加成（CuAAC）的合成范围，在聚合物和材料科学中开创了点击化学概念，已经过去了十年。对聚合物化学家的努力的影响是巨大的，因为这个概念的力量，具有模块化，正交性和多功能性的设计和合成的聚合物材料，很快就被世界各地的高分子研究小组所认识。在这第一次爆发的研究活动之后，在可实现的聚合物构建、正在进行的方法开发和实施方面挑战了CuAAC的边界，以响应对无金属替代品的需求，产生了一个有价值的点击式缀合方法工具箱。由于在各种聚合物体系中应用的可采用的反应的多样性很大，第一次或偶尔点击的用户将面临选择的负担。因此，本观点的主要目的是通过详细的概念分析清楚地表明大分子科学中点击激发化学的最新进展，并提供一些选择程序，使潜在用户能够容易地将他们对点击化学的期望与最先进的技术相匹配。初次或偶尔使用的用户应能够识别和选择最合适的点击，他们的目的启发反应，并最终有助于下一代先进的聚合物材料。
This year, it has been a decade that the concept of click chemistry was pioneered in polymer and material science by the exploration of the synthetic scope of copper-catalyzed azide/alkyne cycloaddition (CuAAC), the click benchmark. The impact on the endeavors of polymer chemists has been substantial because the power of this concept, featuring modularity, orthogonality, and versatility for the design and synthesis of polymeric materials, was recognized very soon in macromolecular research groups worldwide. After this first burst of research activity, challenging the boundaries of CuAAC in terms of attainable polymer constructs, ongoing method development, and implementation, in response to the need for metal-free alternatives, resulted in a valuable toolbox of click-inspired conjugation methods. Because of the large diversity of employable reactions, applied in various polymeric systems, the first-time or occasional click user will be confronted with a burden of choice. Therefore, the principal aim of this Perspective is to clearly denote the recent progress of click-inspired chemistry in macromolecular science by detailed conceptual analysis and to provide some selection procedures, allowing potential users to readily match their expectations of click chemistry to the state-of-the-art. Consequently, first-time or occasional users should be able to identify and select the most appropriate click-inspired reaction for their purposes and eventually contribute to the next generations of advanced polymeric materials.