Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products
Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products
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DOI：
10.1016/j.jmr.2008.03.012
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发表时间：
2008-07-01
影响因子：
2.2
通讯作者：
Vigneron, Daniel B.
中科院分区：
文献类型：
--
作者：
Cunningham, Charles H.;Chen, Albert P.;Vigneron, Daniel B.
动态核极化和溶解的C-13标记的底物，使动态成像的细胞代谢。通常需要获取光谱信息，这使得动态体积数据的获取成为一项挑战。为了实现快速体积成像，设计了光谱-空间激发脉冲以激发碳光谱的单条线。在信号中仅存在单个共振的情况下，回波平面读出轨迹可以用于解析空间信息，每3.5秒给出32 x 32 x 16体素的全体积覆盖。这种高帧速率用于测量正常大鼠模型和前列腺癌小鼠模型中不同组织中的不同乳酸动力学。(c)2008年爱思唯尔公司All rights reserved.
Dynamic nuclear polarization and dissolution of a C-13-labeled substrate enables the dynamic imaging of cellular metabolism. Spectroscopic information is typically acquired, making the acquisition of dynamic volumetric data a challenge. To enable rapid volumetric imaging, a spectral-spatial excitation pulse was designed to excite a single line of the carbon spectrum. With only a single resonance present in the signal, an echo-planar readout trajectory could be used to resolve spatial information, giving full volume coverage of 32 x 32 x 16 voxels every 3.5 s. This high frame rate was used to measure the different lactate dynamics in different tissues in a normal rat model and a mouse model of prostate cancer. (c) 2008 Elsevier Inc. All rights reserved.