The prognostic value of MDR1 gene expression in primary untreated neuroblastoma
The prognostic value of MDR1 gene expression in primary untreated neuroblastoma
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DOI：
10.1016/s0959-8049(97)00229-3
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发表时间：
1997-10-01
影响因子：
8.4
通讯作者：
Norris, MD
中科院分区：
文献类型：
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作者：
Haber, M;Bordow, SB;Norris, MD
MDR1基因表达对儿童神经母细胞瘤生物学的贡献尚不清楚。为了阐明MDR1在这种恶性肿瘤中的作用，我们研究了60个原发性未经治疗的神经母细胞瘤亚群中MDR1表达与患者预后之间的关系，这些神经母细胞瘤的MYCN基因拷贝数和多药耐药相关蛋白（MRP）基因的表达先前已被表征。与MRP基因表达相反，与没有扩增的肿瘤相比，MYCN基因扩增的肿瘤中MDR1表达较低。在缺乏MYCN基因扩增的肿瘤中，观察到MDR1和MRP基因表达之间以及MDR1和MYCN基因表达之间的强相关性（P
The contribution of MDR1 gene expression to the biology of childhood neuroblastoma is unclear. To clarify the role of MDR1 in this malignancy, we examined the relationship between MDR1 expression and patient outcome in subsets of 60 primary untreated neuroblastomas for which MYCN gene copy number and expression of the multidrug resistance-associated-protein (MRP) gene had been previously characterised. In contrast to MRP gene expression, MDR1 expression was lower in tumours with MYCN gene amplification compared with those without amplification. Strong correlations between MDR1 and MRP gene expression, and between MDR1 and MYCN gene expression, were observed in tumours lacking MYCN gene amplification (P