Coordination of Genomic RNA Packaging with Viral Assembly in HIV-1.
Coordination of Genomic RNA Packaging with Viral Assembly in HIV-1.
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DOI：
10.3390/v8070192
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发表时间：
2016-07-14
期刊：
影响因子：
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通讯作者：
Lever AM
中科院分区：
文献类型：
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作者：
Hellmund C;Lever AM
在揭示人类免疫缺陷病毒（艾滋病毒）复制的复杂性方面取得了巨大进展，产生了一个针对病毒复制周期关键方面的药物库。然而，尽管积累了丰富的知识，我们仍然有很多东西要了解某些病毒的过程。其中之一是病毒组装，其中病毒基因组和蛋白质聚集在一起形成感染性后代。在这里，我们审查这个话题的角度来看，如何生产的传染性病毒粒子的路线是精心策划的病毒基因组，我们比较和对比方面的装配机制所采用的HIV-1与其他RNA病毒。
The tremendous progress made in unraveling the complexities of human immunodeficiency virus (HIV) replication has resulted in a library of drugs to target key aspects of the replication cycle of the virus. Yet, despite this accumulated wealth of knowledge, we still have much to learn about certain viral processes. One of these is virus assembly, where the viral genome and proteins come together to form infectious progeny. Here we review this topic from the perspective of how the route to production of an infectious virion is orchestrated by the viral genome, and we compare and contrast aspects of the assembly mechanisms employed by HIV-1 with those of other RNA viruses.