Subchondral bone sclerosis in osteoarthritis: not just an innocent bystander.
Subchondral bone sclerosis in osteoarthritis: not just an innocent bystander.
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DOI：
10.3109/s101650300001
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发表时间：
2003-03-01
影响因子：
2.2
通讯作者：
Martel-Pelletier, J
中科院分区：
文献类型：
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作者：
Lajeunesse, D;Massicotte, F;Martel-Pelletier, J
摘要骨关节炎（OA）是一种复杂的疾病，关节组织在其病理生理过程中起着重要的作用。我们仍然不完全了解是什么引发了软骨的退化和损失。然而，已经表明，由于OA关节中细胞因子和生长因子升高而导致的骨钙素增加起着重要作用。最近的证据表明，软骨下骨组织在OA的进展和/或发生中起关键作用。事实上，软骨下骨组织产生许多类似的促炎细胞因子，并且生长因子参与软骨组织重塑。有趣的是，研究表明，在OA早期出现的潮标中存在裂缝或通道，这表明细胞因子和生长因子从软骨下室运输到覆盖软骨的可能方式。因此，某些骨衍生产品可能驱动软骨代谢。潜在的候选者包括胰岛素样生长因子-1（IGF-1）、转化生长因子-β（TGF-β）、白细胞介素-1 β（IL-1 β）和白细胞介素-6（IL-6）。证明软骨下骨在OA的发生中起作用将大大有助于我们进一步了解这种病理学，并为治疗方法提供新的见解。
Abstract Osteoarthritis (OA) is considered to be a complex illness in which the tissues of the joint play a significant role in the initiation and/or progression of the pathophysiology. We still do not completely understand what initiates the degradation and loss of cartilage. However, it has been suggested that increased catabolism due to elevated cytokines and growth factors in OA joints plays a significant role. Recent evidence suggests a key role for the subchondral bone tissue in the progression and/or initiation of OA. Indeed, the subchondral bone tissue produces a number of similar proinflammatory cytokines, and growth factors are involved in cartilage tissue remodeling. Interestingly, studies have shown the presence of clefts or channels in the tidemark that appears early in OA, indicating a possible way to traffic cytokines and growth factors from the subchondral compartment to the overlying cartilage. Therefore, it is possible that certain bone-derived products drive cartilage metabolism. Potential candidates include insulin-like growth factor-1 (IGF-1), transforming growth factor-beta (TGF-beta) interleukin 1beta (IL-1beta), and interleukin-6 (IL-6). Demonstrating that the subchondral bone plays a role in the initiation of OA would greatly contribute to furthering our knowledge of this pathology and provide new insights for therapeutic approaches.