Histone demethylase JMJD2C: epigenetic regulators in tumors.
Histone demethylase JMJD2C: epigenetic regulators in tumors.
复制标题
组蛋白去甲基化酶 JMJD2C：肿瘤中的表观遗传调节因子
DOI：
10.18632/oncotarget.19176
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发表时间：
2017-10-31
期刊：
影响因子：
--
通讯作者：
Li Q
中科院分区：
文献类型：
--
作者：
Zhang C;Wang Z;Ji Q;Li Q
组蛋白甲基化是表观遗传修饰的主要方式之一，多种组蛋白甲基化酶和去甲基化酶参与了表观遗传调控。JMJD 2C是一种组蛋白赖氨酸脱甲基酶。作为Jumonji-C组蛋白脱甲基酶家族的一员，JMJD 2C能够通过氧化反应使K9（赖氨酸残基9）或K36（赖氨酸残基36）位点的三甲基化或二甲基化组蛋白3和2脱甲基，从而影响异染色质形成、基因组印记、X染色体失活和基因转录调控。JMJD 2C是最早发现的一个参与胚胎发育和干细胞调控的基因。JMJD 2C组蛋白甲基化在多种肿瘤的发生、发展过程中发挥着重要作用，在乳腺癌、前列腺癌、骨肉瘤、血液肿瘤等的发生、发展过程中发挥着重要作用，提示JMJD 2C是一个很有前途的抗癌靶点。本文就JMJD 2C在肿瘤中的研究进展及前景作一综述，为JMJD 2C在肿瘤中的功能应用和治疗潜力提供充分的证据。
Histone methylation is one of the major epigenetic modifications, and various histone methylases and demethylases participate in the epigenetic regulating. JMJD2C has been recently identified as one of the histone lysine demethylases. As one member of the Jumonji-C histone demethylase family, JMJD2C has the ability to demethylate tri- or di-methylated histone 3 and 2 in either K9 (lysine residue 9) or K36 (lysine residue 36) sites by an oxidative reaction, thereby affecting heterochromatin formation, genomic imprinting, X-chromosome inactivation, and transcriptional regulation of genes. JMJD2C was firstly found to involve in embryonic development and stem cell regulation. Afterwards, aberrant status of JMJD2C histone methylation was observed during the formation and development of various tumors, and it has been reported to play crucial roles in the progression of breast cancer, prostate carcinomas, osteosarcoma, blood neoplasms and so on, indicating that JMJD2C represents a promising anti-cancer target. In this review, we will focus on the research progress and prospect of JMJD2C in tumors, and provide abundant evidence for the functional application and therapeutic potential of targeting JMJD2C in tumors.
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