Pulmonary papillary adenoma presenting in central portion: a case report.
Pulmonary papillary adenoma presenting in central portion: a case report.
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中央部肺乳头状腺瘤一例报告
DOI：
10.1186/s13000-015-0425-7
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发表时间：
2015-10-17
影响因子：
2.6
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Lin XY;Han Q;Wang EH;Zhang Y
肺乳头状腺瘤是一种非常罕见的肿瘤，通常发生在肺的周围。在此，我们报告一位17岁的中国女性发生于肺中央的肺乳头状腺瘤。影像学检查在右肺门区偶然发现一个边界清楚的肿块。组织学上，肿瘤主要由大量的乳头状结构组成，内衬柱状至立方状上皮细胞，类似于II型肺细胞。免疫组化染色显示上皮细胞呈弥漫性细胞角蛋白、细胞角蛋白7、TTF-1、EMA、表面活性物质载脂蛋白A、Napsin A、P63和β-catenin阳性。Ki-67增殖指数约为2%。基于形态学特征和免疫组化谱，肿瘤与肺乳头状腺瘤一致。因此，应该注意的是，肺乳头状腺瘤也是中心肿块的可能诊断。
Pulmonary papillary adenoma is a very rare tumor usually presenting in periphery of the lung. Herein, we present a case of pulmonary papillary adenoma located in central portion of the lung in a 17 year-old Chinese female. A well-defined mass was incidentally detected at right pulmonary hilar region by imaging examination. Histologically, the tumor is predominantly composed of abundant papillary structures lined by columnar to cuboidal epithelial cells resembling type II pneumocytes. Immunohistochemical staining showed that the epithelial cells were diffusely positive for cytokeratin, cytokeratin7, TTF-1, EMA, surfactant apoprotein A, Napsin A, P63 and β-catenin. The Ki-67 proliferation index was approximately 2 %. Based on morphologic features and the immunohistochemical profile, the tumor was consistent with pulmonary papillary adenoma. Thus, it should be noted that pulmonary papillary adenoma was also a possible diagnosis for a central mass.