A manually controlled new device for punctuate mechanical stimulation of teeth during functional magnetic resonance imaging studies
A manually controlled new device for punctuate mechanical stimulation of teeth during functional magnetic resonance imaging studies
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DOI：
10.1111/j.1600-051x.2010.01596.x
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发表时间：
2010-09-01
影响因子：
6.7
通讯作者：
Grandin, Cecile B.
中科院分区：
文献类型：
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作者：
Habre-Hallage, Pascale;Hermoye, Laurent;Grandin, Cecile B.
目的设计一种简单、经济的装置，在功能磁共振成像(FMRI)过程中应用标准化的机械穿孔刺激来触发牙周机械感受器。材料和方法利用von Frey单丝在体模和8名志愿者身上测试一种新的手动控制装置。比较了四种不同时间段的区组设计模式。刺激牙齿11、12、13、21、22、23和拇指。最有效的方案包括周期为24小时的S，刺激频率为1赫兹。当刺激牙齿时，无论是同侧、对侧或两侧，初级(S1)和次级(S2)体感区域的激活都是一致的。刺激拇指可激活对侧S1区和同侧或对侧S2区。结论这一创新工具的使用可以进行功能磁共振研究，旨在揭示牙周神经感受器的神经关联，并了解牙齿缺失诱导的可塑性以及最终由骨内种植体取代它们。
P>AimTo design a simple and affordable device that could apply standardized mechanical punctuate stimuli to trigger the periodontal mechanoreceptors during functional magnetic resonance imaging (fMRI).Material and MethodsA new manually controlled device using von Frey monofilaments was tested on a phantom and on eight volunteers. Four block design paradigms with different timing were compared. Teeth 11, 12, 13, 21, 22, 23 and the thumb were stimulated.ResultsThe device did not induce any artefacts in MR images. The most efficient protocol included an epoch duration of 24 s and stimuli delivered at 1 Hz. When stimulating the teeth, activations of the primary (S1) and secondary (S2) somatosensory areas were consistently obtained, either on the ipsilateral, contra-lateral or both sides. Stimulation of the thumb led to activations of the contra-lateral S1 area and either ipsilateral or contra-lateral S2 area.ConclusionThe use of this innovative tool should allow to perform fMRI studies aimed to unveil the neural correlates of periodontal neural receptors, and to understand their plasticity induced by tooth loss and their eventual replacement by endosseous oral implants.