Multiplicative interaction between angiotensin II and K concentration in stimulation of aldosterone.
Multiplicative interaction between angiotensin II and K concentration in stimulation of aldosterone.
复制标题
血管紧张素 II 和 K 浓度在醛固酮刺激中的乘法相互作用。
DOI：
10.1152/ajpendo.1984.247.3.e328
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Scott,RE
中科院分区：
文献类型：
--
作者：
Young,DB;SmithJr,MJ;Jackson,TE;Scott,RE
在一组6只狗中，通过测定醛固酮对3个水平的血管紧张素II的反应，同时保持3个水平的K摄入量，研究了血管紧张素II和血浆K浓度在刺激醛固酮分泌中的相互作用。血管紧张素水平为1）内源性水平，2）输注5 ng X kg-1 X min-1产生的浓度，3）输注10 ng X kg-1 X min-1产生的浓度。每个水平维持5天。三种钾摄入率分别为10、100和200 meq/d，各维持3 wk。分析血管紧张素输注期第1、2和5天的数据。在每种输注水平的第5天，从绘制血浆K（PK）对醛固酮浓度获得的回归为：1）对于未输注（内源性PRA = 0.4 - 0.5ng ANG I X ml-1 X h-1），醛固酮= 5.04 X PK - 16.56; 2）对于5 ng X kg-1 X min-1输注，醛固酮= 12.20 X PK - 39.09; 3）10 ng × kg ~（-1）× min ~（-1）输注时，醛固酮= 35.50 × Pk ~（-119.31）。每个回归与其他两个回归有显著差异（P <0.001）。血浆K轴截距，即醛固酮分泌为零的点，从0、5和10 ng X kg-1 X min-1输注速率回归的值分别为3.29、3.20和3.36。（250字处删节）
The interaction of angiotensin II and plasma K concentration in stimulating aldosterone secretion was studied in a group of six dogs by determining the aldosterone response to three levels of angiotensin II while the dogs were maintained on three levels of K intake. The levels of angiotensin were 1) the endogenous level, 2) the concentration resulting from infusion of 5 ng X kg-1 X min-1, and 3) the concentration resulting from infusion of 10 ng X kg-1 X min-1. Each level was maintained for 5 days. The three rates of K intake were 10, 100, and 200 meq/day, each maintained for 3 wk. Data were analyzed from days 1, 2, and 5 of the angiotensin infusion periods. The regressions obtained from plotting plasma K (PK) versus aldosterone concentration on day 5 of each level of infusion were 1) for no infusion (endogenous PRA = 0.4 to 0.5 ng ANG I X ml-1 X h-1), aldosterone = 5.04 X PK - 16.56; 2) for 5 ng X kg-1 X min-1 infusion, aldosterone = 12.20 X PK - 39.09; and 3) for 10 ng X kg-1 X min-1 infusion, aldosterone = 35.50 X Pk - 119.31. Each regression was significantly different (P less than 0.001) from the other two. The plasma K axis intercepts, which are the points at which aldosterone secretion is zero, were 3.29, 3.20, and 3.36 for the regression from the 0, 5, and 10 ng X kg-1 X min-1 infusion rates, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)