microRNAs in inflammatory alveolar bone defect: A review.
microRNAs in inflammatory alveolar bone defect: A review.
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DOI：
10.1111/jre.12819
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发表时间：
2020-12
影响因子：
3.5
通讯作者：
Yun Yuan;Hongming Zhang;Hui Huang
中科院分区：
文献类型：
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作者：
Yun Yuan;Hongming Zhang;Hui Huang
炎症性牙槽骨缺损是由牙周病原体引起的，是临床上最常见的口腔疾病之一，以牙周支持组织损伤为特征。MicroRNAs(MiRNAs)可参与多种炎症性病变，并通过转录后调控靶基因来调节骨代谢。近年来的研究证实，一些miRNAs在炎症性牙槽骨缺损的发生发展过程中起着重要作用。因此，我们就miRNAs与炎症性牙槽骨缺损的相关性进行综述，并阐明其可能的机制，为防治炎症性牙槽骨缺损提供新的思路。
Inflammatory alveolar bone defects are caused by periodontal pathogens, are one of the most common oral diseases in the clinic, and are characterized by periodontal support tissue damage. MicroRNAs (miRNAs) can participate in a variety of inflammatory lesions and modulate bone metabolism through the posttranscriptional regulation of target genes. In recent years, studies have confirmed that some miRNAs play significant roles in the development of inflammatory alveolar bone defects. Therefore, we reviewed the correlation between miRNAs and inflammatory alveolar bone defects and elucidated the underlying mechanisms to provide new ideas for the prevention and treatment of inflammatory alveolar bone defects.