Global, regional, national burden of breast cancer in 185 countries: evidence from GLOBOCAN 2018
Global, regional, national burden of breast cancer in 185 countries: evidence from GLOBOCAN 2018
复制标题
DOI：
10.1007/s10549-020-06083-6
复制
发表时间：
2021-01-30
影响因子：
3.8
通讯作者：
Sharma, Rajesh
中科院分区：
文献类型：
--
作者：
Sharma, Rajesh
本研究旨在调查2018年185个国家的乳腺癌负担。方法乳腺癌的发病率、死亡率和患病率估计值来自GLOBOCAN 2018。使用乳腺癌负担指数（BRCBI）衡量乳腺癌的总体负担，BRCBI是一种新的指数，包括年龄标准化发病率（ASIR）、年龄标准化死亡率（ASMR）、死亡率与发病率比（MIR）、患病率与发病率比（PIR）和患病率与死亡率比（PMR）。在全球范围内，乳腺癌估计造成626，679人死亡，年龄标准化率为13/100，000; 2018年诊断出210万例病例，年龄标准化率为46.3/100，000。ASIR变化22倍，从5/100，000（不丹）到113.2/100，000（比利时）。ASMR变化13倍，从2.7/100，000（不丹）到36.9/100，000（斐济）。HDI与ASIR（r = 0.73）、PIR（r = 0.98）和PMR（r = 0.85）呈正梯度;而与MIR呈负相关（r =-0.83）。BRCBI从索马里的0.70到韩国的78.92，与人类发展指数呈正相关（r = 0.76）。2018年，如果各国按照其人类发展指数执行，那么2013-2018年期间可以挽救另外46，823名女性的生命，累计333，304人的生命。结论：发展中国家和低资源经济体的乳腺癌负担沉重，需要采取全面的癌症管理和控制方法，包括肿瘤基础设施，以提供具有成本效益的筛查，诊断，治疗和姑息治疗服务，提高乳腺癌意识，减轻风险因素。
Purpose This study aims to examine the burden of breast cancer in 185 countries in 2018. Methods The estimates of incidence, mortality, and prevalence of breast cancer were drawn from GLOBOCAN 2018. The overall burden of breast cancer was gauged using breast cancer burden index (BRCBI)-a novel index comprising age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), mortality-to-incidence ratio (MIR), prevalence-to-incidence ratio (PIR), and prevalence-to-mortality ratio (PMR). The socioeconomic status of countries was measured using human development index (HDI) Results Globally, breast cancer was responsible for an estimated 626,679 deaths at age-standardized rate of 13/100,000; there were 2.1 million cases diagnosed in 2018 at age-standardized rate of 46.3/100,000. The ASIR varied 22-fold from 5/100,000 (Bhutan) to 113.2/100,000 (Belgium). The ASMR varied 13-fold from 2.7/100,000 (Bhutan) to 36.9/100,000 (Fiji). The HDI exhibited a positive gradient with ASIR (r = 0.73), PIR (r = 0.98), and PMR (r = 0.85); with MIR, however, it exhibited a negative association (r = - 0.83). The BRCBI spanned from 0.70 in Somalia to 78.92 in South Korea and exhibited a positive association with HDI (r = 0.76). An additional 46,823 female lives in 2018 and a cumulative total of 333,304 lives could have been saved over 2013-2018, had countries performed as per their HDI. Conclusions The substantial burden of breast cancer in developing and low-resource economies calls for a holistic approach to cancer management and control that includes oncologic infrastructure to provide cost-effective screening, diagnostic, therapeutic, and palliative services, greater breast cancer awareness, and mitigation of risk factors.