Testing standards for sporicides
Testing standards for sporicides
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DOI：
10.1016/j.jhin.2010.08.011
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发表时间：
2011-03-01
影响因子：
6.9
通讯作者：
Humphreys, P. N.
中科院分区：
文献类型：
--
作者：
Humphreys, P. N.
由于对能够处理艰难梭菌孢子污染的产品的要求，杀孢子剂在医疗保健环境中具有相当重要的作用。用来验证杀孢子剂活性声明的杀孢子剂检测标准是评价商用杀孢子剂的一个重要工具。在欧洲，有许多杀孢子剂检测标准，通常用于验证商业杀孢子剂的说法。然而，这些标准反映杀孢子剂在卫生保健环境中的实际应用的程度是有限的，因为它们使用长时间接触(=30分钟)，并且不涉及表面污染。目前已有使用受污染的载体而不是孢子悬浮液的替代国际标准，经济合作与发展组织目前正在制定一套统一的标准，其设计比目前可用的欧洲标准更现实。本文综述了目前可用的杀孢子剂检测标准，重点介绍了它们之间的主要程序差异以及它们在多大程度上反映了杀孢子剂产品的实际应用。还强调和讨论了与应用欧洲杀孢子剂标准方法有关的一些常见问题和错误。最后，找出并讨论了目前可用的测试标准中的差距。(C)2010年医院感染学会。爱思唯尔有限公司出版。保留所有权利。
Sporicidal products are of considerable importance in healthcare environments due to the requirement for products that are capable of dealing with contamination with Clostridium difficile spores. Sporicidal testing standards to validate the claims of sporicidal activity are an important tool in the evaluation of commercial sporicides. Within Europe there are a number of sporicidal testing standards which are often used to validate the claims of commercial sporicides. However, the extent to which these standards reflect the practical application of sporicides in healthcare settings is limited since they employ long contact times (>= 30 min) and do not involve surface contamination. Alternative international standards are available which employ contaminated carriers rather than spore suspensions, and the Organisation for Economic Cooperation and Development is currently developing a unified set of standards which are more realistic in their design than the currently available European standards. This paper reviews the currently available testing standards for sporicides, highlighting the key procedural differences between them and the extent to which they reflect the practical application of sporicidal products. Some of the common problems and errors associated with the application of the European sporicidal standard methods are also highlighted and discussed. Finally gaps in the currently available testing standards are identified and discussed. (C) 2010 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.