Individual Drusen Segmentation and Repeatability and Reproducibility of Their Automated Quantification in Optical Coherence Tomography Images.
Individual Drusen Segmentation and Repeatability and Reproducibility of Their Automated Quantification in Optical Coherence Tomography Images.
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DOI：
10.1167/tvst.6.1.12
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发表时间：
2017-02
影响因子：
3
通讯作者：
Rubin DL
中科院分区：
文献类型：
--
作者：
de Sisternes L;Jonna G;Greven MA;Chen Q;Leng T;Rubin DL
介绍一种在谱域光学相干断层扫描（SD-OCT）中分割个体玻璃疣的新方法，并评估其准确性以及从分割结果中提取的玻璃疣量化的重复性/再现性。我们的方法使用视网膜色素上皮（RPE）外边界的平滑插值，拟合到接近布鲁赫膜的候选位置，以识别内部RPE或内部节段边界的实质性提升区域，然后独立地分离和评估单个晶簇。该研究包括来自129名患者的192只眼。玻璃疣分割的准确性进行了评估，测量重叠率（OR）与手动标记，也比较结果与以前提出的方法。在重复SD-OCT体积对中研究了自动玻璃疣定量的扫描方案的重复性和再现性，并与商业工具（Cirrus HD-OCT）测量的结果进行了比较。我们的分割方法比之前提出的方法产生了更高的准确性，与手动标记（0.72 ± 0.09 OR）的差异与测量的阅片者内和阅片者间变异性（分别为0.78 ± 0.09和0.77 ± 0.09）相似。自动定量显示出高重复性和再现性，在玻璃疣面积和体积测量中显示出比商业软件更稳定的扫描方案行为。玻璃疣斜率和平均强度的测量结果显示，各方案之间存在显著差异。通过我们的方法产生的自动玻璃疣轮廓显示出有希望的准确结果，这些结果在使用相同或不同扫描协议的重复扫描中似乎相对稳定。所提出的方法代表了一种可行的工具来测量和跟踪玻璃疣测量在早期或中期年龄相关性黄斑变性患者。
To introduce a novel method to segment individual drusen in spectral-domain optical coherence tomography (SD-OCT), and evaluate its accuracy, and repeatability/reproducibility of drusen quantifications extracted from the segmentation results. Our method uses a smooth interpolation of the retinal pigment epithelium (RPE) outer boundary, fitted to candidate locations in proximity to Bruch's Membrane, to identify regions of substantial lifting in the inner-RPE or inner-segment boundaries, and then separates and evaluates individual druse independently. The study included 192 eyes from 129 patients. Accuracy of drusen segmentations was evaluated measuring the overlap ratio (OR) with manual markings, also comparing the results to a previously proposed method. Repeatability and reproducibility across scanning protocols of automated drusen quantifications were investigated in repeated SD-OCT volume pairs and compared with those measured by a commercial tool (Cirrus HD-OCT). Our segmentation method produced higher accuracy than a previously proposed method, showing similar differences to manual markings (0.72 ± 0.09 OR) as the measured intra- and interreader variability (0.78 ± 0.09 and 0.77 ± 0.09, respectively). The automated quantifications displayed high repeatability and reproducibility, showing a more stable behavior across scanning protocols in drusen area and volume measurements than the commercial software. Measurements of drusen slope and mean intensity showed significant differences across protocols. Automated drusen outlines produced by our method show promising accurate results that seem relatively stable in repeated scans using the same or different scanning protocols. The proposed method represents a viable tool to measure and track drusen measurements in early or intermediate age-related macular degeneration patients.