Potential Drug-Drug Interactions in Infant, Child, and Adolescent Patients in Children's Hospitals
Potential Drug-Drug Interactions in Infant, Child, and Adolescent Patients in Children's Hospitals
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DOI：
10.1542/peds.2014-2015
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发表时间：
2015-01-01
期刊：
影响因子：
8
通讯作者：
Feudtner, Chris
中科院分区：
文献类型：
--
作者：
Feinstein, James;Dai, Dingwei;Feudtner, Chris
背景和目标：住院婴儿、儿童和青少年通常在住院期间接触多种不同的药物，增加了潜在药物相互作用 (PDDI) 的风险。我们评估了在儿童医院接受治疗的儿科患者的 PDDI 暴露患病率和特征。方法：这项回顾性队列研究包括在美国各地儿童医院住院的 21 岁患者。 PDDI 使用 MicroMedix DRUG-REAX 系统进行鉴定。我们计算了暴露于 PDDI 的患者，并根据相互作用的严重性进行分层； PDDI 暴露的每日和累积计数；结果：2011 年 498 956 例住院治疗中，49% 与 >= 1 PDDI 相关，所有住院治疗中 5% 出现“禁忌”PDDI，41% 出现“严重”PDDI，28% 出现“中度”PDDI，11% 出现“轻微”PDDI。 25% 的 PDDI 涉及阿片类药物，其次是抗感染药物 (17%)、神经药物 (15%)、胃肠药物 (13%) 和心血管药物 (13%)。所有 PDDI 暴露的一半是由于特定药物对发生在
BACKGROUND AND OBJECTIVES: Hospitalized infants, children, and adolescents are typically exposed to numerous distinct medications during inpatient admissions, increasing their risk of potential drug-drug interactions (PDDIs). We assessed the prevalence and characteristics of PDDI exposure of pediatric patients treated in children's hospitals.METHODS: This retrospective cohort study included patients,21 years old hospitalized in children's hospitals throughout the United States. PDDIs were identified by using the MicroMedex DRUG-REAX system. We calculated the patients exposed to PDDIs, stratified according to the seriousness of the interaction; daily and cumulative counts of PDDI exposures; and characterization of the cited potential adverse effects.RESULTS: Of 498 956 hospitalizations in 2011, 49% were associated with >= 1 PDDI, with a "contraindicated" PDDI occurring in 5% of all hospitalizations, a "major" PDDI present in 41%, a "moderate" PDDI in 28%, and a "minor" PDDI in 11%. Opioids were involved in 25% of all PDDIs, followed by antiinfective agents (17%), neurologic agents (15%), gastrointestinal agents (13%), and cardiovascular agents (13%). One-half of all PDDI exposures were due to specific drug pairs occurring in