CaesarStone Silicosis Disease Resurgence Among Artificial Stone Workers
CaesarStone Silicosis Disease Resurgence Among Artificial Stone Workers
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DOI：
10.1378/chest.11-1321
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发表时间：
2012-08-01
期刊：
影响因子：
9.6
通讯作者：
Shitrit, David
中科院分区：
文献类型：
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作者：
Kramer, Mordechai R.;Blanc, Paul D.;Shitrit, David
背景：矽肺是一种进行性、纤维化、职业性肺部疾病，由吸入可吸入的结晶二氧化硅引起。这种疾病可以通过适当的工作场所实践来预防。我们系统地评估了转诊至我们中心进行肺移植的患者中的矽肺爆发情况。方法：这项回顾性队列分析包括 1997 年 1 月至 2010 年 12 月期间转诊至以色列国家肺移植计划进行评估的所有被诊断为矽肺的患者。我们还将以色列因矽肺引起的肺移植 (LTX) 发生率与国际心肺移植协会 (ISHLT) 登记处的发生率进行了比较。在为期 14 年的研究期间，25 名矽肺患者被转诊进行评估，其中 10 名患者继续接受 LTX。所有患者都通过干切割接触到一种相对较新的人造装饰石材产品，该产品具有高结晶二氧化硅含量，主要用于厨房台面和浴室固定装置。这些患者患有中度至重度限制性肺病。两名患者出现进行性大规模纤维化；没有人出现急性矽肺病（硅蛋白沉积症）。 3 名患者在随访期间死亡，未服用 LTX。根据 ISHLT 登记发病率，预计会出现 0.68 例硅肺病例，而不是观察到的 10 例（发病率，14.6；95% CI，7.02-26.8）。 结论：这次硅肺病爆发很重要，因为全世界都在使用这种和类似的高硅含量人造石产品。除非采取有效的预防措施并执行现有的安全措施，否则可能会发生更多情况。胸部 2012； 142(2):419-424
Background: Silicosis is a progressive, fibrotic, occupational lung disease resulting from inhalation of respirable crystalline silica. This disease is preventable through appropriate workplace practices. We systematically assessed an outbreak of silicosis among patients referred to our center for lung transplant.Methods: This retrospective cohort analysis included all patients with a diagnosis of silicosis who were referred for evaluation to the National Lung Transplantation Program in Israel from January 1997 through December 2010. We also compared the incidence of lung transplantation (LTX) due to silicosis in Israel with that of the International Society for Heart and Lung Transplantation (ISHLT) registry.Results: During the 14-year study period, 25 patients with silicosis were referred for evaluation, including 10 patients who went on to undergo LTX. All patients were exposed by dry cutting a relatively new, artificial, decorative stone product with high crystalline silica content used primarily for kitchen countertops and bathroom fixtures. The patients had moderate-to-severe restrictive lung disease. Two patients developed progressive massive fibrosis; none manifested acute silicosis (silicoproteinosis). Three patients died during follow-up, without LTX. Based on the ISHLT registry incidence, 0.68 silicosis cases would have been expected instead of the 10 observed (incidence ratio, 14.6; 95% CI, 7.02-26.8).Conclusions: This silicosis outbreak is important because of the worldwide use of this and similar high-silica-content, artificial stone products. Further cases are likely to occur unless effective preventive measures are undertaken and existing safety practices are enforced. CHEST 2012; 142(2):419-424