Massachusetts general hospital Covid-19 registry reveals two distinct populations of hospitalized patients by race and ethnicity.
Massachusetts general hospital Covid-19 registry reveals two distinct populations of hospitalized patients by race and ethnicity.
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DOI：
10.1371/journal.pone.0244270
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Foulkes AS
中科院分区：
文献类型：
--
作者：
Bassett IV;Triant VA;Bunda BA;Selvaggi CA;Shinnick DJ;He W;Lu F;Porneala BC;Cao T;Lubitz SA;Meigs JB;Hsu J;Foulkes AS
目的：评估在马萨诸塞州总医院住院的新冠肺炎患者中不同种族/民族的临床特征和预后的差异。马萨诸塞州卫生院新冠肺炎登记处包括在该院住院的确诊的SARS-CoV-2感染患者，并基于手动病历审查和从电子健康记录中提取数据。我们评估了2020年3月11日至2020年5月4日期间因新冠肺炎住院的N=866名患者在人口统计学、并发症和14天预后方面的差异。总体而言，43%的新冠肺炎患者是女性，中位年龄为60.4岁[智商=(48.2，75)]，11.3%是黑人/非西班牙裔，35.2%是西班牙裔。西班牙裔患者占患者的35.2%，比白人/非西班牙裔患者年轻[中位年龄51岁；智商=(40.6，61.6)比72岁；(58.0，81.7)(p<；0.001)]。拉美裔患者在出现护理前症状出现的时间更长(中位数5vs3d，p=0.039)，但更有可能被送回家进行自我隔离而不是住院(29%vs16%，p<；0.001)。西班牙裔患者的合并症较少，但ICU或死亡率(34%比36%)与之相当。尽管如此，西班牙裔患者在发病14天后恢复的比例更高(62%比45%，p<；0.001；在多变量调整模型中OR=1.99p=0.011)，更少的死亡(2%比18%，p<；0.001)。与白人/非西班牙裔患者相比，住院的西班牙裔患者更年轻，合并疾病更少；尽管ICU护理或死亡率相似，但康复的比例更大。这些结果对公共卫生政策以及临床试验的设计和进行都有影响。
To evaluate differences by race/ethnicity in clinical characteristics and outcomes among hospitalized patients with Covid-19 at Massachusetts General Hospital (MGH). The MGH Covid-19 Registry includes confirmed SARS-CoV-2-infected patients hospitalized at MGH and is based on manual chart reviews and data extraction from electronic health records (EHRs). We evaluated differences between White/Non-Hispanic and Hispanic patients in demographics, complications and 14-day outcomes among the N = 866 patients hospitalized with Covid-19 from March 11, 2020—May 4, 2020. Overall, 43% of patients hospitalized with Covid-19 were women, median age was 60.4 [IQR = (48.2, 75)], 11.3% were Black/non-Hispanic and 35.2% were Hispanic. Hispanic patients, representing 35.2% of patients, were younger than White/non-Hispanic patients [median age 51y; IQR = (40.6, 61.6) versus 72y; (58.0, 81.7) (p<0.001)]. Hispanic patients were symptomatic longer before presenting to care (median 5 vs 3d, p = 0.039) but were more likely to be sent home with self-quarantine than be admitted to hospital (29% vs 16%, p<0.001). Hispanic patients had fewer comorbidities yet comparable rates of ICU or death (34% vs 36%). Nonetheless, a greater proportion of Hispanic patients recovered by 14 days after presentation (62% vs 45%, p<0.001; OR = 1.99, p = 0.011 in multivariable adjusted model) and fewer died (2% versus 18%, p<0.001). Hospitalized Hispanic patients were younger and had fewer comorbidities compared to White/non-Hispanic patients; despite comparable rates of ICU care or death, a greater proportion recovered. These results have implications for public health policy and the design and conduct of clinical trials.
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DOI：
10.15585/mmwr.mm6915e3
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garg S;Kim L;Whitaker M;O'Halloran A;Cummings C;Holstein R;Prill M;Chai SJ;Kirley PD;Alden NB;Kawasaki B;Yousey-Hindes K;Niccolai L;Anderson EJ;Openo KP;Weigel A;Monroe ML;Ryan P;Henderson J;Kim S;Como-Sabetti K;Lynfield R;Sosin D;Torres S;Muse A;Bennett NM;Billing L;Sutton M;West N;Schaffner W;Talbot HK;Aquino C;George A;Budd A;Brammer L;Langley G;Hall AJ;Fry A
通讯作者：
Fry A
影响因子：
3.8
作者：
Clark, Eva;Fredricks, Karla;Weatherhead, Jill
通讯作者：
Weatherhead, Jill
DOI：
10.3961/jpmph.20.256
发表时间：
2020-07-01
期刊：
Journal of preventive medicine and public health = Yebang Uihakhoe chi
影响因子：
--
作者：
Hawkins, Devan
通讯作者：
Hawkins, Devan
DOI：
10.15585/mmwr.mm6927a3
发表时间：
2020-07-10
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Hsu HE;Ashe EM;Silverstein M;Hofman M;Lange SJ;Razzaghi H;Mishuris RG;Davidoff R;Parker EM;Penman-Aguilar A;Clarke KEN;Goldman A;James TL;Jacobson K;Lasser KE;Xuan Z;Peacock G;Dowling NF;Goodman AB
通讯作者：
Goodman AB
DOI：
10.1001/jama.2020.6775
发表时间：
2020-01-01
期刊：
JAMA, Journal of the American Medical Association
影响因子：
--
作者：
Richardson, Safiya;Hirsch, Jamie S.;,
通讯作者：
,