Nanotemplating of Biodegradable Polymer Membranes for Constant-Rate Drug Delivery
Nanotemplating of Biodegradable Polymer Membranes for Constant-Rate Drug Delivery
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DOI：
10.1002/adma.200903439
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发表时间：
2010-06-04
影响因子：
29.4
通讯作者：
Desai, Tejal A.
中科院分区：
文献类型：
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作者：
Bernards, Daniel A.;Desai, Tejal A.
利用氧化锌纳米模板制备了纳米孔可生物降解聚合物(聚己内酯)(见图)。化学表征证实了模板的去除，细胞毒性的初步测试证明了基本的生物相容性。模型小分子和蛋白质的扩散分别为一级和零级，表明这些纳米孔膜可能用于蛋白质类药物的控制释放。
A nanoporous biodegradable polymer (polycaprolactone) is fabricated utilizing a zinc oxide nanotemplate (see figure). Chemical characterization verifies removal of the template, and preliminary tests on the cytotoxicity demonstrate basic bio-compatibility. Diffusion of a model small molecule and a protein are shown to be first and zero order, respectively, indicating these nanoporous membranes may be useful for controlled release of protein-based therapeutics.