Kidney disease in the first-degree relatives of African-Americans with hypertensive end-stage renal disease
Kidney disease in the first-degree relatives of African-Americans with hypertensive end-stage renal disease
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DOI：
10.1016/s0272-6386(96)90356-x
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发表时间：
1996-03-01
影响因子：
13.2
通讯作者：
Rostand, SG
中科院分区：
文献类型：
--
作者：
Bergman, S;Key, BO;Rostand, SG
在美国，非裔美国人 (AA) 接受治疗的终末期肾病 (ESRD) 的发病率是白人的四倍。这既不能用高血压和糖尿病的患病率增加来解释，也不能用社会经济问题来解释。为了调查 AA 肾病的家族风险，我们检查了阿拉巴马州杰斐逊县 472 名 AA 透析患者的记录。采用严格的标准，我们确定了 85 例仅与高血压相关的 ESRD 指标病例 (H-ESRD)。我们检查了 75 个指示病例的记录，并研究了 40 名患者的一级亲属。患有 H-ESRD 的男性和女性人数相似（分别为 38 人和 37 人）。透析开始时的年龄没有统计学差异（女性 53.7 +/- 13.5 岁 [+/-SD]，男性 49.2 +/- 12.2 岁；P = 0.0863）。我们在参与家庭的 40 名指示病例中的 26 名 (65%) 中发现了肾脏疾病的证据。 40个家庭全部患有高血压（100%），24个家庭（60%）患有糖尿病。 75 名 H-ESRD 指数患者中，有 18 名患者的一级亲属患有 ESRD。总的来说，我们在 75 个家庭中的 35 个 (47%) 中发现了肾脏疾病的证据。我们的结论是，患有 H-ESRD 的 AA 家族的肾脏疾病具有很强的一致性。 (C) 1996 年，国家肾脏基金会 (National Kidney Foundation, Inc.)
The incidence of treated end-stage renal disease (ESRD) in the United States is four times more frequent in African-Americans (AAs) than in whites. This is explained neither by a greater prevalence of hypertension and diabetes mellitus nor by socioeconomic issues. To investigate familial risk of renal disease in AAs, we examined the records of 472 AA dialysis patients in Jefferson County, Alabama. Applying strict criteria, we identified 85 index cases of ESRD associated only with hypertension (H-ESRD). We examined the records of 75 index cases and studied the first-degree relatives of 40 patients. The numbers of men and women with H-ESRD were similar (38 and 37, respectively). There was no statistical difference in age at the onset of dialysis (women 53.7 +/- 13.5 years [+/-SD] and men 49.2 +/- 12.2 years; P = 0.0863). We found evidence for renal disease in 26 of 40 (65%) index cases with participating families. Hypertension was present in all 40 families (100%) and diabetes mellitus was present in 24 families (60%). Eighteen of the 75 H-ESRD index patients had a first-degree relative with ESRD. In total, we found evidence for renal disease in 35 of 75 (47%) families. We conclude that there is a strong concordance of renal disease in the families of AAs with H-ESRD. (C) 1996 by the National Kidney Foundation, Inc.