The frequency-dependent stimulation effects of rTMS on the performance of problem-solving tasks and ongoing oscillations
The frequency-dependent stimulation effects of rTMS on the performance of problem-solving tasks and ongoing oscillations
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DOI：
10.1192/j.eurpsy.2022.661
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发表时间：
2022-09-01
影响因子：
7.8
通讯作者：
Kawasaki, M.
中科院分区：
文献类型：
--
作者：
Miyauchi, E.;Kawasaki, M.
最近的研究表明，在线重复经颅磁刺激（rTMS）可以诱导局部夹带正在进行的内源性振荡活动，影响认知性能，效果可能取决于振荡的功能。然而，很少有人知道特定任务的频率的影响，特别是当使用在线rTMS范式。我们先前的脑电图（EEG）研究表明，额叶θ节律与问题解决任务中的认知放弃过程有关。在这项研究中，我们结合在线rTMS和EEG检查rTMS的频率依赖性刺激对问题解决任务和持续振荡的性能的影响。我们假设θ频率的rTMS会诱导持续的θ活动并加速放弃行为。在解决问题的任务中应用rTMS，条件如下：单独的theta（4- 6 Hz）-和alpha（9- 13 Hz）-TMS，无TMS和假TMS;条件的顺序在参与者中平衡。我们的研究结果表明，θ-频率rTMS应用程序引起θ振幅的增加，缩短了放弃的反应，而控制α-频率rTMS应用程序引起α振幅的增加，但没有改变放弃的反应。本研究证明了使用特定的任务相关的刺激频率和目标位置的认知和行为性能的调制的有效性。此外，考虑到抑郁症中放弃行为和反刍之间的密切相似性，认知放弃过程的神经调节可能导致通过rTMS治疗抑郁症的新干预。没有明显的关系。
Recent studies suggest that online repetitive transcranial magnetic stimulation (rTMS) can induce local entrainment of ongoing endogenous oscillatory activity that impacts cognitive performance, and the effect may depend on the function of the oscillation. However, little is known about the effects of task-specific frequencies, especially when using an online rTMS paradigm. Our previous electroencephalogram (EEG) study showed that the frontal theta rhythm is associated with the cognitive giving-up processes during problem-solving tasks. In this study, we combined online rTMS and EEG to examine the frequency-dependent stimulation effects of rTMS on the performance of problem-solving tasks and ongoing oscillations. We hypothesized that rTMS at the theta frequency would induce ongoing theta activity and accelerate the giving-up behaviour. rTMS was applied during problem-solving tasks with the following conditions: individual theta (4-6Hz)- and alpha (9-13Hz)-TMS, no-TMS, and sham-TMS; the order of conditions was counterbalanced across participants. Our results showed that theta-frequency rTMS application induced an increase in theta amplitudes and shortened the giving-up response, while a control alpha-frequency rTMS application induced an increase in alpha amplitudes, but did not change giving-up responses. This study demonstrated the effectiveness of using specific task-relevant stimulation frequency and target location for the modulation of cognitive and behavioral performance. Furthermore, considering the close resemblance between giving-up behaviour and rumination in depression, neuromodulation of cognitive giving-up processes may lead to a new intervention to treat depression by rTMS. No significant relationships.