Copper-catalyzed asymmetric conjugate addition of diethylzinc to α,β-unsaturated imines derived from α-aminoacids.: Enantioselective synthesis of γ-substituted α-dehydroaminoesters
Copper-catalyzed asymmetric conjugate addition of diethylzinc to α,β-unsaturated imines derived from α-aminoacids.: Enantioselective synthesis of γ-substituted α-dehydroaminoesters
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DOI：
10.1021/ol062294k
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发表时间：
2006-11-09
期刊：
影响因子：
5.2
通讯作者：
Vicario, Javier
中科院分区：
文献类型：
--
作者：
Palacios, Francisco;Vicario, Javier
[图表]报道了使用 TADDOL 衍生的亚磷酰胺复合物，通过铜催化二乙基锌与 α,β-不饱和亚胺的不对称共轭加成，高度对映选择性合成在 γ 位具有立构中心的 α-脱氢氨基酸。
[GRAPHICS]A highly enantioselective synthesis of alpha-dehydroaminoacids with a stereogenic center in the gamma position through copper-catalyzed asymmetric conjugate addition of diethylzinc to alpha,beta-unsaturated imines using a TADDOL-derived phosphoramidite complex is reported.