HYPOPHAGIA FOLLOWING DIETARY OBESITY
HYPOPHAGIA FOLLOWING DIETARY OBESITY
复制标题
DOI：
10.1016/0031-9384(86)90137-x
复制
发表时间：
1986-01-01
影响因子：
2.9
通讯作者：
RAMIREZ, I
中科院分区：
文献类型：
--
作者：
RAMIREZ, I
两个实验检测了当老鼠从高脂肪饮食转变为低脂肪饮食时发生的低吞噬症。在第一个实验中，喂食高脂肪食物八周的老鼠比喂低脂肪食物的老鼠多重79克。取消高脂肪饮食会导致至少四周的食物摄入量减少。将大鼠体重减少24小时禁食并没有改变低噬食症的时间进程。在喂食高脂饮食期间和之后，血浆中游离甘油、游离脂肪酸和酮的水平都会升高；这表明，即使在停止高脂饮食之后，喂食高脂肪饮食也会增加脂肪氧化。在第二个实验中，喂食高脂饮食四周的大鼠增加了体重和体脂。在喂食高脂肪食物后，让大鼠挨饿两天并不能改变随后的低吞食症，也不能改变体内脂肪的百分比。这一结果模式类似于以前在胰岛素治疗期间终止肥胖后看到的模式。这一结果与脂肪氧化持续增加是低噬症的原因这一观点是一致的。
Two experiments examined the hypophagia that occurs when rats are switched from a high-fat to a low-fat diet. In the first experiment, rats fed a high-fat diet for eight weeks weighed 79 g more than rats fed a low-fat diet. Removal of the high-fat diet led to reduced food intake for at least four weeks. Reducing the body weight of the rats by a 24 hour fast did not alter the time course of the hypophagia. Plasma levels of free glycerol, free fatty acids and ketones were elevated during and after feeding the high-fat diet; suggesting that feeding a high-fat diet increases fat oxidation even after the high-fat diet is withdrawn. In the second experiment, feeding rats the high-fat diet for four weeks increased body weight and body fat. Starving the rats for two days after feeding the high-fat diet did not alter subsequent hypophagia and did not alter the percentage of body fat. This pattern of results is similar to that previously seen following termination of obesity-induring insulin treatment. The results are consistent with the idea that a persistent increase in fat oxidation is responsible for the hypophagia.