Sustained immunologic and virologic efficacy after four years of highly active antiretroviral therapy in human immunodeficiency virus infected children in Thailand
Sustained immunologic and virologic efficacy after four years of highly active antiretroviral therapy in human immunodeficiency virus infected children in Thailand
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DOI：
10.1097/inf.0b013e318125720a
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发表时间：
2007-10-01
影响因子：
3.6
通讯作者：
Sirisanthana, Virat
中科院分区：
文献类型：
--
作者：
Puthanakit, Thanyawee;Aurpibul, Linda;Sirisanthana, Virat
我们报告了高活性抗逆转录病毒治疗（HAART）对107名抗逆转录病毒naive人类免疫缺陷病毒（HIV）感染的泰国儿童的长期疗效。在意向治疗分析中，经过192周的HAART治疗后，70%的儿童检测不到HIV RNA滴度。平均CD4细胞百分比从5.3%增加到26.6%。在这种资源贫乏的环境中，尽管在疾病晚期才开始治疗，但HAART对感染艾滋病毒的儿童是有效的。
We report the long-term efficacy of highly active antiretroviral therapy (HAART) in 107 antiretroviral-naive human immunodeficiency virus (HIV)-infected Thai children. In an intention-to-treat analysis, 70% of the children had undetectable HIV RNA titers after 192 weeks of HAART. The mean CD4 cell percentage increased from 5.3% to 26.6%. HAART is effective for HIV-infected children in this resource-poor setting despite initiation of treatment in the advanced stage of disease.