Effect of aging on autonomic function in individuals with severe motor and intellectual disabilities
Effect of aging on autonomic function in individuals with severe motor and intellectual disabilities
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DOI：
10.1016/s0387-7604(03)00005-6
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发表时间：
2003-08-01
影响因子：
1.7
通讯作者：
Mitsudome, A
中科院分区：
文献类型：
--
作者：
Hamamoto, K;Ogawa, A;Mitsudome, A
严重运动和智力残疾（SMID）患者的自主神经功能经常受到异常调节。在这项研究中，我们评估了SMID患者的自主神经功能，并确定了年龄对其的影响。该研究包括21名SMID患者和15名健康青少年（对照组）。为了确定年龄的影响，将SMID患者分为老年组（老年）和年轻组（年轻）。采用24小时霍尔特心电图记录的心率变异性（HRV）功率谱分析评估自主神经功能。计算HRV的低频和高频分量（LH和HF）。LF和HF之间的比率（LF/HF）被用作交感神经调制的指标，而单独的HF被用作副交感神经调制的指标。对照组LH/HF白天高于夜间，而HE则相反。因此，在对照组中观察到交感神经和副交感神经活动的昼夜节律。而SMID患者的LF/HF无昼夜节律。老年SMID组的HF高于年轻组，老年SMID组中有8例患者表现出昼夜节律，而年轻组中无患者表现出昼夜节律。这些结果表明，交感神经系统抑制在老年和年轻SMID患者。然而，虽然副交感神经系统在年轻的SMID患者中受到抑制，但随着年龄的增长而被激活。(C)2003 Elsevier Science B. V.保留所有权利。
Autonomic nervous function is often abnormally regulated in individuals with severe motor and intellectual disabilities (SMID). In this study, we assessed autonomic nervous function of patients with SMID and determined how it was influenced by age. The study included 21 individuals with SMID and 15 healthy adolescents (control). To determine the effect of aging, the patients with SMID were divided into an older age group (Old) and younger age group (Young). Autonomic nervous function was assessed using power spectral analysis of heart rate variability (HRV) for 24-h Holter electrocardiogram recordings. The low- and high-frequency components (LH and HF) of HRV were calculated. The ratio between LF and HF (LF/HF) was used as an indicator of sympathetic modulation, while HF alone was used as an indicator of parasympathetic modulation. The LH/HF in the control group was higher in the daytime than at nighttime, while HE had an opposite pattern of change. Therefore, circadian rhythms were observed in the control group for both sympathetic and parasympathetic nervous activities. In contrast, the LF/HF in patients with SMID had no circadian rhythm. The HF was higher in the Old SMID group than in the Young group, and it exhibited a circadian rhythm in eight patients in the Old SMID group versus none of the patients in the Young group. These findings suggest that the sympathetic nervous system is suppressed in both old and young patients with SMID. However, while the parasympathetic nervous system is suppressed in younger patients with SMID, it is activated with increasing age. (C) 2003 Elsevier Science B.V. All rights reserved.