The effect of inhaled leukotriene D4 in humans.
The effect of inhaled leukotriene D4 in humans.
复制标题
吸入白三烯 D4 对人体的影响。
DOI：
10.1164/arrd.1985.131.3.368
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Bernstein,PR
中科院分区：
文献类型：
--
作者：
Smith,LJ;Greenberger,PA;Patterson,R;Krell,RD;Bernstein,PR
白三烯D4（LTD 4）是一种强有力的支气管收缩剂，可能在哮喘中发挥重要作用。为了更好地描述LTD 4对人气道的作用，正常、鼻炎和哮喘受试者接受了LTD 4和乙酰甲胆碱的吸入激发试验。在所有受试者中，LTD 4浓度的增加导致比气道传导率和30%肺活量时的流量平行降低，通过部分用力呼气动作测量（）。这些变化的发生与FEV 1的任何降低或功能性残气量的增加无关。LTD 4的气道反应在2 - 3 min内达到最大，持续约30 min，并在1 - 3 h内消退。未观察到晚期效应。鼻炎患者对LTD 4的敏感性是正常人的3 - 5倍（p < 0.01），哮喘患者对LTD 4的敏感性是正常人的25 - 100倍（p < 0.001）。所有3组受试者对LTD 4的敏感性是乙酰甲胆碱的250至850倍。发现LTD 4浓度与乙酰甲胆碱浓度之间存在显著相关性，乙酰甲胆碱浓度使比气道传导率降低35%（r = 0.874; p < 0.006），使比气道传导率降低30%（r = 0.751; p < 0.04）。这些结果证实，LTD 4是一种有效的支气管收缩剂，具有快速起效和长期效应。与以前的报道相反，我们发现LTD 4对大气道和小气道的作用相同，哮喘和正常受试者对LTD 4的敏感性增加程度与乙酰甲胆碱相同。
Leukotriene D4(LTD4) is a potent bronchoconstrictor that may play an important role in asthma. To better characterize the effect of LTD4on human airways, normal, rhinitic, and asthmatic subjects underwent inhalation challenge tests with LTD4and methacholine. In all subjects increasing concentrations of LTD4produced a parallel decrease in specific airway conductance and flow at 30% of vital capacity measured from a partial forced expiratory maneuver (). These changes occurred independent of any decrease in FEV1or increase in functional residual capacity. The airway response to LTD4was maximal within 2 to 3 min, persisted for approximately 30 min, and resolved over 1 to 3 h. Late effects were not seen. Rhinitic subjects were 3 to 5 times (p < 0.01) and asthmatic subjects were 25 to 100 times (p < 0.001) more sensitive than were normal subjects to LTD4. All 3 groups of subjects were 250 to 850 times more sensitive to LTD4than to methacholine. Significant correlations were found between the concentration of LTD4and the concentration of methacholine that produced a 35% decrease in specific airway conductance (r = 0.874; p < 0.006) and a 30% decrease in (r = 0.751; p < 0.04). These results confirm that LTD4is a potent bronchoconstrictor in humans, with a rapid onset of action and a prolonged effect. In contrast to previous reports, we found that LTD4has an equal effect on both large and small airways and that both asthmatic and normal subjects have the same degree of increased sensitivity to LTD4as to methacholine.