PARTIAL SLEEP-DEPRIVATION REDUCES NATURAL-KILLER-CELL ACTIVITY IN HUMANS
PARTIAL SLEEP-DEPRIVATION REDUCES NATURAL-KILLER-CELL ACTIVITY IN HUMANS
复制标题
DOI：
10.1097/00006842-199411000-00004
复制
发表时间：
1994-11-01
影响因子：
3.3
通讯作者：
SMITH, TL
中科院分区：
文献类型：
--
作者：
IRWIN, M;MASCOVICH, A;SMITH, TL
睡眠障碍，通过主观报告或对睡眠的脑电(EEG)评估来衡量，与严重抑郁症患者的自然杀伤(NK)细胞活性降低有关。为了测试与情绪障碍无关的睡眠不足是否会改变白天的细胞免疫功能，研究了深夜部分睡眠剥夺对23名内科和精神科健康男性志愿者NK细胞活性的影响。在凌晨3点到7点之间的一夜睡眠剥夺后，23名受试者中有18人的NK细胞活性降低，平均溶血活性显著降低(p<；.01)，达到三个独立基线平均值的72%。在恢复夜间睡眠一晚后，NK细胞活性已恢复到基线水平。这些数据表明，睡眠与自然免疫力的调节有关，并表明即使是轻微的睡眠干扰也会导致NK细胞活性的降低。
Sleep disturbance, measured by either subjective report or electroencephalographic (EEG) assessment of sleep, correlates with a reduction of natural killer (NK) cell activity in major depression. To test whether sleep loss independent of mood disturbance alters daytime values of cellular immune function, the effect of late-night partial sleep deprivation on NK cell activity was studied in 23 medically and psychiatrically healthy male volunteers. After a night of sleep deprivation between 3 and 7 AM, NK cell activity was reduced in 18 of the 23 subjects with average lytic activity reduced significantly (p < .01) to a level 72% of the mean of three separate baseline values. After a night of resumed nocturnal sleep, NK cell activity had returned to baseline levels. These data implicate sleep in the modulation of natural immunity and demonstrate that even modest disturbances of sleep produce a reduction of NK cell activity.