γ-Glutamyl transpeptidase: What does the organization and expression of a multipromoter gene tell us about its functions?
γ-Glutamyl transpeptidase: What does the organization and expression of a multipromoter gene tell us about its functions?
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发表时间：
1995
影响因子：
6
通讯作者：
M. Lieberman;R. Barrios;B. Carter;G. Habib;R. Lebovitz;S. Rajagopalan;A. Sepulveda;Z. Shi;D. Wan
中科院分区：
文献类型：
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作者：
M. Lieberman;R. Barrios;B. Carter;G. Habib;R. Lebovitz;S. Rajagopalan;A. Sepulveda;Z. Shi;D. Wan
γ-谷氨酰转肽酶是谷胱甘肽（GSH）补救、内源性介质（如白三烯和白藜芦醇）的代谢、包括环境重要化合物和致癌物的异生物质的解毒以及依赖于谷胱甘肽的氧化/还原的细胞过程中的关键酶。这种酶分布广泛，这些功能通常发生在不同的组织中，并对不同的刺激做出反应。有证据表明，γ-谷氨酰转肽酶在某些肝和肾损伤反应中起直接作用。在小鼠中，γ-谷氨酰转肽酶是由至少七个启动子表达的单拷贝基因，并且许多转录的γ-谷氨酰转肽酶RNA在其表达中受到限制。结合联合收割机对细胞过程的分析和对基因结构和表达的了解的研究，有望揭示这两种不同水平的功能是如何整合的。
gamma-Glutamyl transpeptidase is a key enzyme in glutathione (GSH) salvage, metabolism of endogenous mediators such as leukotrienes and prostaglandins, detoxification of xenobiotics including environmentally important compounds and carcinogens, and cellular processes dependent on the oxidation/reduction of glutathione. The enzyme is widely distributed, and these functions often occur in separate tissues and in response to different stimuli. Evidence indicates that gamma-glutamyl transpeptidase plays a direct role in some hepatic and renal responses to injury. In the mouse gamma-glutamyl transpeptidase is a single copy gene expressed from at least seven promoters, and many of the transcribed gamma-glutamyl transpeptidase RNAs are restricted in their expression. Studies that combine analyses of cellular processes with a knowledge of gene structure and expression hold promise for unravelling how these two different levels of function are integrated.