Update on pathogenesis, management, and control of Plasmodium vivax.
Update on pathogenesis, management, and control of Plasmodium vivax.
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DOI：
10.1097/qco.0000000000000867
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发表时间：
2022-10-01
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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这是对间日疟原虫流行病学、发病机制、疾病表现、治疗以及控制和消除创新的综述。在这里，我们回顾了最近的文献并总结了间日疟原虫管理方面的新进展和持续挑战。间日疟原虫在人类宿主中具有复杂的生命周期，影响疾病的严重程度和治疗方案。越来越多的数据表明，脾脏和骨髓中存在隐性病毒库，这可能导致慢性间日疟原虫感染，并可能导致疾病严重程度。绘制间日疟原虫氯喹耐药性地理空间流行病学的方法正在取得进展，这些方法将为当地的治疗指南提供信息。间日疟原虫治疗需要 8-氨基喹啉来消除休眠肝脏阶段。有证据表明，可能需要更高剂量的 8-氨基喹啉才能彻底治愈热带常复发菌株。间日疟原虫是一个重大的全球健康问题。最近在了解间日疟原虫生物学的复杂性和抗疟疾治疗的优化方面取得了进展。旨在制定间日疟原虫控制和消除计划最佳实践的研究正在进行中。
This is a review of Plasmodium vivax epidemiology, pathogenesis, disease presentation, treatment and innovations in control and elimination. Here we examine the recent literature and summarize new advances and ongoing challenges in the management of P. vivax. P. vivax has a complex life cycle in the human host which impacts disease severity and treatment regimens. There is increasing data for the presence of cryptic reservoirs in the spleen and bone marrow which may contribute to chronic vivax infections and possibly disease severity. Methods to map the geospatial epidemiology of P. vivax chloroquine resistance are advancing, and they will inform local treatment guidelines. P. vivax treatment requires an 8-aminoquinoline to eradicate the dormant liver stage. Evidence suggests that higher doses of 8-aminoquinolines may be needed for radical cure of tropical frequent-relapsing strains. P. vivax is a significant global health problem. There have been recent developments in understanding the complexity of P. vivax biology and optimization of anti-malarial therapy. Studies toward the development of best practices for P. vivax control and elimination programs are ongoing.