Do diurnal salivary cortisol curves carry meaningful information about the regulatory biology of the HPA axis in healthy humans?
Do diurnal salivary cortisol curves carry meaningful information about the regulatory biology of the HPA axis in healthy humans?
复制标题
每日唾液皮质醇曲线是否携带有关健康人类 HPA 轴调节生物学的有意义的信息？
DOI：
10.1016/j.psyneuen.2023.106031
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发表时间：
2023
影响因子：
3.7
通讯作者：
Rajaram,Nirmala
中科院分区：
文献类型：
--
作者：
Abelson,JamesL;Sánchez,BrisaN;Mayer,StefanieE;Briggs,Hedieh;Liberzon,Israel;Rajaram,Nirmala
唾液皮质醇应激生物标志物已被广泛用于流行病学工作，以记录压力和健康状况不佳之间的联系。在下丘脑-垂体-肾上腺（HPA）轴调节生物学中，几乎没有努力进行实地友好的皮质醇测量，这可能与描绘从压力暴露到有害健康结果的机械途径有关。在这里，我们利用了一个健康的便利样本（n = 140），以检查广泛收集的唾液皮质醇的措施和可用的实验室探针HPA轴调节生物学之间的正常联系。参与者在一个月内的6天内每天提供9份唾液样本，同时参与日常活动，并参加5项调节测试（肾上腺皮质激素刺激，地塞米松/促肾上腺皮质激素释放激素刺激，甲吡酮，地塞米松抑制和特里尔社会压力测试）。对数回归被用来测试特定的预测皮质醇曲线组件的监管变量，并广泛探索非预测协会。我们发现支持3个原始假设中的2个，显示（1）皮质醇昼夜下降与通过地塞米松抑制测量的反馈敏感性之间的关联，以及（2）早晨皮质醇水平与肾上腺敏感性之间的关联。我们没有发现中央驱动（甲吡酮测试）和一天结束时唾液水平之间的联系。我们证实了一个先验的期望，有限的联系之间的调节生物学和昼夜唾液皮质醇的措施，超出了那些预测。这些数据支持一个新兴的重点措施有关的流行病学压力工作的昼夜下降。他们提出了关于其他曲线成分的生物学意义的问题，包括早晨的皮质醇水平，也许还有CAR（皮质醇觉醒反应）。如果早晨皮质醇动力学与压力有关，那么在压力适应和压力-健康联系中对肾上腺敏感性的更多研究可能是必要的。
Salivary cortisol stress biomarkers have been extensively used in epidemiological work to document links between stress and ill health. There has been little effort to ground field friendly cortisol measures in the hypothalamic-pituitary-adrenal (HPA) axis regulatory biology that is likely relevant to delineating mechanistic pathways leading from stress exposure to detrimental health outcomes. Here, we utilized a healthy convenience sample (n = 140) to examine normal linkages between extensively collected salivary cortisol measures and available laboratory probes of HPA axis regulatory biology. Participants provided 9 saliva samples per day over 6 days within a month, while engaging in usual activities, and also participated in 5 regulatory tests (adrenocorticoptripin stimulation, dexamethasone/corticotropin-releasing-hormone stimulation, metyrapone, dexamethasone suppression, and Trier Social Stress Test). Logistical regression was used to test specific predictions linking cortisol curve components to regulatory variables and to explore widely for non-predicted associations. We found support for 2 of 3 original hypotheses, showing associations (1) between cortisol diurnal decline and feedback sensitivity as measured by dexamethasone suppression, and (2) between morning cortisol levels and adrenal sensitivity. We did not find links between central drive (metyrapone test) and end of day salivary levels. We confirmed an a priori expectation of limited linkage between regulatory biology and diurnal salivary cortisol measures, beyond those predicted. These data support an emerging focus on measures related to diurnal decline in epidemiological stress work. They raise questions about the biological meaning of other curve components, including morning cortisol levels, and perhaps CAR (Cortisol Awakening Response). If morning cortisol dynamics are linked to stress, more work on adrenal sensitivity in stress adaptation and stress-health links may be warranted.