Synthesis and characterization of grafted nanohydroxyapatites using functionalized surface agents
Synthesis and characterization of grafted nanohydroxyapatites using functionalized surface agents
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DOI：
10.1021/la063517i
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发表时间：
2007-06-05
期刊：
影响因子：
3.9
通讯作者：
Darr, Jawwad A.
中科院分区：
文献类型：
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作者：
Haque, Saba;Rehman, Ihtesham;Darr, Jawwad A.
合成羟基磷灰石，HA [Ca-10(PO4)(6)(OH)(2)] 是一种生物活性材料，其化学性质与生物磷灰石（骨的矿物相）（一种纳米复合材料）相似。用于骨替代的合成生物复合材料由聚合物和羟基磷灰石组成，在疲劳负载下具有局限性，因为两相之间的弱机械结合可能导致界面失效。 HA 和聚合物基质的化学偶联可以提供改善聚合物和 HA 相之间的界面结合的方法。在此，我们报告了通过两步过程开发化学偶联纳米生物复合材料的第一步。我们描述了表面接枝羟基磷灰石 (SG-HA) 的合成和表征，它具有反应性 C=C 官能团。在未来的工作中，我们将报告第二步，即通过共聚反应将该官能团与聚合物偶联，得到化学偶联的纳米生物复合材料。本文报道的 SG-HA 通过一系列方法进行表征，包括 P-31 和 C-13 魔角旋转 (MAS)-NMR、傅里叶变换红外 (FTIR) 和拉曼光谱。
Synthetic hydroxyapatite, HA [Ca-10(PO4)(6)(OH)(2)], is a bioactive material that is chemically similar to biological apatite, the mineral phase of bone (a nanocomposite material). Synthetic biocomposites, comprising a polymer and hydroxyapatite that are used for bone replacement, have limitations when loaded under fatigue in that the weak mechanical bond between the two phases can result in failure at the interface. Chemical coupling of the HA and polymer matrix may provide a means of improving the interfacial bonding between the polymer and HA phases. Herein, we report our first steps toward developing chemically coupled nano-biocomposites via a two-step process. We describe the synthesis and characterization of surface-grafted hydroxyapatite (SG-HA), which possesses a reactive C=C functional group. In future work, we will report on the second step, namely the coupling of this functional group to a polymer by a copolymerization reaction to give a chemically coupled nano-biocomposite. The SG-HA reported herein was characterized by a range of methods including P-31 and C-13 magic-angle spinning (MAS)-NMR, Fourier transform infrared (FTIR), and Raman spectroscopy.