Visceral adipose tissue and the ratio of visceral to subcutaneous adipose tissue are greater in adults with than in those without spinal cord injury, despite matching waist circumferences
Visceral adipose tissue and the ratio of visceral to subcutaneous adipose tissue are greater in adults with than in those without spinal cord injury, despite matching waist circumferences
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DOI：
10.1093/ajcn/87.3.600
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发表时间：
2008-03-01
影响因子：
7.1
通讯作者：
Buchholz, Andrea C.
中科院分区：
文献类型：
--
作者：
Edwards, Lesley A.;Bugaresti, Joanne M.;Buchholz, Andrea C.
背景：腹部肥胖，特别是内脏脂肪组织（VAT），与冠心病（CHD）风险增加有关。尽管脊髓损伤（SCI）患者CHD死亡率风险升高，但SCI患者腹部脂肪组织积聚和腰围（WC）的有效性均未确定。目的：本研究的目的是比较总脂肪组织（达特）、内脏脂肪组织（VAT）、皮下脂肪组织（SAT）以及VAT与SAT的比值（VAT：SAT）之间的成年人与SCI和年龄，性别和WC匹配健全（AB）的控制，并确定WC和增值税之间的关系在这两个群体。设计：31例男性和女性（n = 15例SCI和16例AB），平均（+/- SD）年龄为38.9 +/- 7.9岁，参与了这项横断面研究。在L-4-L-5通过计算机断层扫描定量腹部脂肪组织。结果：SCI患者的平均VAT（P 0.003）、VAT：SAT（P = 0.034）和达特（P = 0.055）均比AB对照组高58%、48%和26%。组间平均SAT无显著差异。两组各部位的WC与VAT相关（SCI：0.905
Background: Abdominal obesity, particularly visceral adipose tissue (VAT), is associated with an increased risk of coronary heart disease (CHD). Despite an elevated risk of CHD mortality in persons with spinal cord injury (SCI), neither abdominal adipose tissue accumulation nor the validity of waist circumference (WC) has been determined in persons with SCI.Objectives: The objectives of this study were to compare total adipose tissue (TAT), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and the ratio of VAT to SAT (VAT:SAT) between adults with SCI and age-, sex-, and WC-matched able-bodied (AB) controls and to determine the relation between WC and VAT in both groups.Design: Thirty-one men and women (n = 15 SCI and 16 AB) with a mean (+/- SD) age of 38.9 +/- 7.9 y participated in this cross-sectional study. Abdominal adipose tissue was quantified by computed tomography at L-4-L-5. WC was measured at 3 sites: lowest rib, iliac crest, and the midpoint between the lowest rib and iliac crest.Results: Persons with SCI had a 58% greater mean VAT (P 0.003),48% greater mean VAT:SAT (P = 0.034), and 26% greater mean TAT (P = 0.055) than did matched AB controls after differences in weight were accounted for. Mean SAT was not significantly different between groups. WC at all sites was correlated with VAT in both groups (SCI: 0.905