Modeling approach to diameter breakpoint determination
Modeling approach to diameter breakpoint determination
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DOI：
10.1016/s0732-8893(99)00130-3
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发表时间：
2000-03-01
影响因子：
2.9
通讯作者：
Craig, BA
中科院分区：
文献类型：
--
作者：
Craig, BA
在确定区域直径断点时，误差率界方法直接关注观察到的差异百分比（非常大、主要和次要）。然而，由于所研究的分离株数量、MIC和区域直径之间的药物特异性关系、分离株相对于MIC中间区域的位置以及每种检测的固有变异性，这些百分比是可变的。为了克服潜在的抽样问题，提出了一个层次模型，明确占每个这些因素和概率，从这个模型被用来确定直径breakpoints-A模拟研究，以证明改进的一致性，这个模型为基础的程序。三个已发表的散点图的应用表明其可解释性的优势。(C)2000 Elsevier Science Inc. All rights reserved.
In determining zone diameter breakpoints, the error-rate bounded method focuses directly on the observed discrepancy percentages (very major, major, and minor). These percentages, however, are quire variable due to the number or isolates investigated, the drug-specific relationship between MIC and zone diameter, the location of the isolates relative to the MIC intermediate zone, and the inherent variability of each test. To overcome potential sampling problems, a hierarchical model is proposed which explicitly accounts for each of these factors and probabilities from this model are used to determine diameter breakpoints A simulation study is performed to demonstrate the improved consistency of this model-based procedure. Application to three published scatterplots demonstrate its interpretability advantages. (C) 2000 Elsevier Science Inc. All rights reserved.