mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats.
mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats.
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MTOR在大鼠大鼠的巨大肩袖撕裂和肩上神经损伤后，通过SREBP-1和PPARγ调节脂肪浸润。
DOI：
10.1002/jor.22254
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发表时间：
2013-05
影响因子：
2.8
通讯作者：
Feeley, Brian T.
中科院分区：
文献类型：
--
作者：
Joshi, Sunil K.;Liu, Xuhui;Samagh, Sanjum P.;Lovett, David H.;Bodine, Sue C.;Kim, Hubert T.;Feeley, Brian T.
Rotator cuff tears (RCTs) are among the most common injuries seen in orthopedic patients. Chronic tears can result in the development of muscular atrophy and fatty infiltration. Despite the prevalence of RCTs, little is known about the underlying molecular pathways that produce these changes. Recently, we have shown that mammalian target of rapamycin (mTOR) signaling plays an important role in muscle atrophy that results from massive RCTs in a rat model. The purpose of this study was therefore to extend our understanding of mTOR signaling and evaluate its role in fatty infiltration after a combined tendon transection and suprascapular nerve denervation surgery. Akt/mTOR signaling was significantly increased and resulted in the up-regulation of two transcription factors: SREBP-1 and PPARγ. We also saw an increase in expression of adipogenic markers: C/EBP-α and FASN. Upon treatment with rapamycin, an inhibitor of mTOR, we observed a decrease in mTOR signaling, activity of transcription factors, and reduction in fatty infiltration. Therefore, our study suggests that mTOR signaling mediates rotator cuff fatty infiltration via SREBP-1 and PPARγ. Clinically, our finding may alter current treatment methods to address rotator cuff fatty infiltration. © 2012 Orthopaedic Research Society.
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影响因子：
7.7
作者：
Houde VP;Brûlé S;Festuccia WT;Blanchard PG;Bellmann K;Deshaies Y;Marette A
通讯作者：
Marette A
DOI：
10.2106/00004623-200101000-00010
发表时间：
2001-01-01
影响因子：
5.3
作者：
Cofield, RH;Parvizi, J;Rowland, CM
通讯作者：
Rowland, CM
影响因子：
7.7
作者：
Kim, JE;Chen, J
通讯作者：
Chen, J
影响因子：
2.8
作者：
Frey, Eric;Regenfelder, Felix;Fuchs, Bruno
通讯作者：
Fuchs, Bruno
DOI：
10.2106/00004623-200409000-00016
发表时间：
2004-09-01
影响因子：
5.3
作者：
Gerber, C;Meyer, DC;Von Rechenberg, B
通讯作者：
Von Rechenberg, B