Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis.
Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis.
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DOI：
10.3960/jslrt.56.109
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
H. Nakamine;M. Yamakawa;T. Yoshino;T. Fukumoto;Y. Enomoto;I. Matsumura
中科院分区：
文献类型：
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作者：
H. Nakamine;M. Yamakawa;T. Yoshino;T. Fukumoto;Y. Enomoto;I. Matsumura
朗格汉斯细胞（LC）组织细胞增生症（LCH）和LC肉瘤（LCS）是由具有朗格汉斯细胞（LC）形态和表型特征的细胞组成的增殖过程，尽管后者可能已经失去了这些特征中的一些。由于最近的研究更可能是LCH和LCS的肿瘤性质，因此可以更好地表征LC增生的类别。LCH和LCS在日常病理实践中很少见，但准确描述这些病变是很重要的。为此，构建了涵盖LC和相关细胞增殖的概述。本大纲的方案尤其基于评估边界病变、肿瘤转分化以及与正常对应部分的相似程度。此外，组织和更新的组织细胞和树突状细胞增殖目前的分类方案。
Langerhans cell (LC) histiocytosis (LCH) and LC sarcoma (LCS) are proliferative processes consisting of cells having morphologic and phenotypic features of Langerhans cells (LCs), although the latter may have lost some of these features. Because neoplastic nature of LCH as well as LCS is more likely by recent studies, a category of LC hyperplasia can be better characterized. LCH and LCS are rarely seen in daily pathology practice, but it is important to accurately characterize these lesions. For this purpose, an outline covering proliferations of LC and related cells was constructed. The scheme of this outline is based especially on evaluating borderline lesions, neoplastic trans-differentiation, and degree of similarity with the normal counter-parts. In addition, the organization and update of the current classification scheme for histiocytic and dendritic-cell proliferations is presented.