Synthetic studies of microsclerodermins. A stereoselective synthesis of a core building block for (2S,3R,4S,5S,6S,11E)-3-amino-6-methyl-12-(4-methoxyphenyl)-2,4,5-trihydroxydodec-11-enoic acid (AMMTD)

Synthetic studies of microsclerodermins. A stereoselective synthesis of a core building block for (2S,3R,4S,5S,6S,11E)-3-amino-6-methyl-12-(4-methoxyphenyl)-2,4,5-trihydroxydodec-11-enoic acid (AMMTD)
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DOI:
10.1016/s0040-4039(97)00522-4
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发表时间:
1997-04-28
影响因子:
1.8
通讯作者:
Shioiri, T
Shioiri, T
中科院分区:
化学4区
文献类型:
--
作者:
Sasaki, S;Hamada, Y;Shioiri, T

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A core building block 3 for (2S,3R,4S,5S,6S,11E)-3-aminod-methyl-12-(4-methoxyphenyl)-2,4,5-trihydroxydoda. -11-enoic acid (2, AMMTD) has been efficiently synthesized using the sharpless asymmetric dihydroxylation and the Dondoni's furan addition to a nitrone derivative as key steps. The 2-furyl group has been used as the carboxylsynthon. (C) 1997 Elsevier Science Ltd.