The multifaceted nature of retinoid transport and metabolism.
The multifaceted nature of retinoid transport and metabolism.
复制标题
DOI：
10.3978/j.issn.2304-3881.2014.05.04
复制
发表时间：
2014-06-01
影响因子：
8
通讯作者：
Blaner, William S
中科院分区：
文献类型：
--
作者：
Li, Yang;Wongsiriroj, Nuttaporn;Blaner, William S
自一个多世纪前发现以来，维甲酸一直是研究最多的脂溶维生素。与大多数维生素不同，维甲酸在体内以相对较高的浓度储存，以缓冲营养不足。直到最近，人们一直认为，视黄醇与视黄醇结合蛋白(RBP4)结合是唯一重要的视黄醇组织递送途径。然而，最近的发现表明，类维甲酸可以通过多种重叠的传递途径被传递到组织中，包括乳糜粒、极低密度脂蛋白(VLDL)和低密度脂蛋白(LDL)、与白蛋白结合的维甲酸、视黄醇和维甲酸的水溶性β-葡萄糖醛酸类化合物，以及维生素A原胡萝卜素。这篇综述将集中于解释对维甲酸代谢和体内运输的这种不断演变的理解。
Since their discovery over a century ago, retinoids have been the most studied of the fat-soluble vitamins. Unlike most vitamins, retinoids are stored at relatively high concentrations in the body to buffer against nutritional insufficiency. Until recently, it was thought that the sole important retinoid delivery pathway to tissues involved retinol bound to retinol-binding protein (RBP4). More recent findings, however, indicate that retinoids can be delivered to tissues through multiple overlapping delivery pathways, involving chylomicrons, very low density lipoprotein (VLDL) and low density lipoprotein (LDL), retinoic acid bound to albumin, water soluble beta-glucuronides of retinol and retinoic acid, and provitamin A carotenoids. This review will focus on explaining this evolving understanding of retinoid metabolism and transport within the body.