Mitochondria from the Outside in: The Relationship Between Inter-Organelle Crosstalk and Mitochondrial Internal Organization.
Mitochondria from the Outside in: The Relationship Between Inter-Organelle Crosstalk and Mitochondrial Internal Organization.
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DOI：
10.1177/25152564221133267
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Friedman, Jonathan R
中科院分区：
文献类型：
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作者：
Friedman, Jonathan R
膜结合细胞器的一个基本作用是细胞过程的区室化和组织。线粒体执行大量的代谢化学反应，并且为了有效地调节这些反应，细胞器将其内膜组织成不同的形态结构域，包括其特征性的嵴膜。近年来，越来越明显的重要性的结构特征是线粒体外部和其他细胞器在膜接触位点（MCSs）之间的相互连接。线粒体与细胞中几乎所有其他细胞器（包括内质网、脂滴和溶酶体）形成MCS，以协调整体细胞代谢与线粒体代谢。然而，这些MCSs不仅促进细胞器之间的代谢物运输，而且直接影响线粒体内的物理形状和功能组织。在这篇综述中，我们强调了最近的进展，我们了解其他细胞器和线粒体之间的物理连接如何直接和间接地影响线粒体的内部结构。
A fundamental role of membrane-bound organelles is the compartmentalization and organization of cellular processes. Mitochondria perform an immense number of metabolic chemical reactions and to efficiently regulate these, the organelle organizes its inner membrane into distinct morphological domains, including its characteristic cristae membranes. In recent years, a structural feature of increasing apparent importance is the inter-connection between the mitochondrial exterior and other organelles at membrane contact sites (MCSs). Mitochondria form MCSs with almost every other organelle in the cell, including the endoplasmic reticulum, lipid droplets, and lysosomes, to coordinate global cellular metabolism with mitochondrial metabolism. However, these MCSs not only facilitate the transport of metabolites between organelles, but also directly impinge on the physical shape and functional organization inside mitochondria. In this review, we highlight recent advances in our understanding of how physical connections between other organelles and mitochondria both directly and indirectly influence the internal architecture of mitochondria.