Clinical and biological characteristics of adult biphenotypic acute leukemia in comparison with that of acute myeloid leukemia and acute lymphoblastic leukemia: a case series of a Chinese population
Clinical and biological characteristics of adult biphenotypic acute leukemia in comparison with that of acute myeloid leukemia and acute lymphoblastic leukemia: a case series of a Chinese population
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DOI：
10.3324/haematol.2008.003202
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发表时间：
2009-07-01
期刊：
影响因子：
--
通讯作者：
Qiu, Hui-Ying
中科院分区：
文献类型：
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作者：
Xu, Xiao-Qian;Wang, Jian-Min;Qiu, Hui-Ying
背景双表型急性白血病是一种难以诊断的罕见疾病。它显示出骨髓和淋巴谱系的特征。目前尚缺乏针对中国人群双表型急性白血病的研究。我们在此对我院七年多来的双表型急性白血病的临床和生物学特征以及转归进行全面调查。设计和方法我们回顾性分析了根据法美英（FAB）分类诊断的 452 例成人急性白血病患者和根据欧洲免疫学特征组诊断的双表型急性白血病患者。 分别为白血病 (EGIL) 分类。对双表型急性白血病患者的生物学特征、治疗反应和转归进行检查，并与同期诊断的完整随访资料的急性髓系白血病和急性淋巴细胞白血病患者进行比较。结果在452例急性白血病患者中，21例（4.6%）被诊断为双表型急性白血病。其中，B淋巴和髓系分化14例（66.7%），T淋巴和髓系分化5例（23.8%），T/B淋巴系分化1例（4.8%），三系分化1例（4.8%）。与急性髓细胞白血病和急性淋巴细胞白血病相比，双表型急性白血病患者的CD34抗原表达、不良核型和髓外浸润的发生率显着升高（p
BackgroundBiphenotypic acute leukemia is a rare disorder that is difficult to diagnose. It displays features of both myeloid and lymphoid lineage. There is still a lack of studies in biphenotypic acute leukemia in a Chinese population. We present here a comprehensive investigation of the clinical and biological characteristics, and outcome of biphenotypic acute leukemia in our hospital in over a seven year period.Design and MethodsWe retrospectively analyzed 452 adult acute leukemia patients diagnosed according to French-American-British (FAB) classification and biphenotypic acute leukemia diagnosed according to European Group for the Immunological Characterization of Leukemias (EGIL) classification, respectively. Biological characteristics, response to treatment, and outcome were examined in biphenotypic acute leukemia patients and compared with that in acute myeloid leukemia and acute lymphoblastic leukemia patients with complete follow-up profiles diagnosed in the same period.ResultsOf 452 acute leukemia patients, 21 cases (4.6%) were diagnosed as biphenotypic acute leukemia. Among them, 14 (66.7%) were B lymphoid and myeloid, 5 (23.8%) were T lymphoid and myeloid, one (4.8%) was T/B lymphoid and one (4.8%) was trilineage differentiation. When compared with acute myeloid leukemia and acute lymphoblastic leukemia, patients with biphenotypic acute leukemia showed significantly higher incidence of CD34 antigen expression, unfavorable karyotypes, and extramedullary infiltration (p