The role of models in translating within-host dynamics to parasite evolution.
The role of models in translating within-host dynamics to parasite evolution.
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DOI：
10.1017/s0031182015000815
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发表时间：
2016-06
期刊：
影响因子：
2.4
通讯作者：
Mideo N
中科院分区：
文献类型：
--
作者：
Greischar MA;Reece SE;Mideo N
数学建模提供了一种有效的方法来挑战关于寄生虫进化的传统智慧，并研究寄生虫为什么在宿主体内“做他们所做的事情”。当直觉无法解释观察到的模式时，当必须考虑更复杂的生物学时，当实验和统计方法可能误导时，模型可以揭示。我们描述了宿主内感染动力学模型如何改进实验设计，并重点介绍了疟疾的案例研究，以突出模型和数据之间的整合如何指导对寄生虫适应性在三个方面的理解：（1）慢性感染的适应意义;（2）毒力和传播之间的权衡潜力;（3）媒介内动力学的影响。我们强调，模型往往是有用的，当他们突出意想不到的模式在寄生虫的进化，而不是揭示为什么直觉产生错误的答案，什么样的理论和数据的组合是需要推进理解。
Mathematical modelling provides an effective way to challenge conventional wisdom about parasite evolution and investigate why parasites ‘do what they do’ within the host. Models can reveal when intuition cannot explain observed patterns, when more complicated biology must be considered, and when experimental and statistical methods are likely to mislead. We describe how models of within-host infection dynamics can refine experimental design, and focus on the case study of malaria to highlight how integration between models and data can guide understanding of parasite fitness in three areas: (1) the adaptive significance of chronic infections; (2) the potential for tradeoffs between virulence and transmission; and (3) the implications of within-vector dynamics. We emphasize that models are often useful when they highlight unexpected patterns in parasite evolution, revealing instead why intuition yields the wrong answer and what combination of theory and data are needed to advance understanding.